TY - JOUR
T1 - Chronic high dose captopril decreases total heart rate variability and increases heart rate in C57BL/6J mice
AU - Touma, F
AU - Chew, Valerie Suk Peng
AU - Chua, Wendy Chen-Nee
AU - Jelinek, H
AU - Wong, Peter T H
AU - Spence, I
AU - McLachlan, Craig Steven
PY - 2009
Y1 - 2009
N2 - The effects of high dose captopril, within the therapeutic range, on autonomic activity are unknown in those with normal cardiovascular function. Thus the study aims were to assess the effects of high dose captopril on autonomic function in mice. Autonomic activity was measured using heart rate variability (HRV). ECG recordings were obtained from 18 Male C57BL/6J mice (20-25 g) subdivided into control (N=8) or mice receiving oral captopril (0.688 mg/ml captopril in the drinking water for 6 weeks, N=10). HRV results for linear and non-linear parameters were attenuated following chronic captopril for 6 weeks compared to control. Captopril was associated with a trend for an increase in average heart rate and approximate entropy (ApEn), a non-linear measure of HRV decreased significantly compared to control (p
AB - The effects of high dose captopril, within the therapeutic range, on autonomic activity are unknown in those with normal cardiovascular function. Thus the study aims were to assess the effects of high dose captopril on autonomic function in mice. Autonomic activity was measured using heart rate variability (HRV). ECG recordings were obtained from 18 Male C57BL/6J mice (20-25 g) subdivided into control (N=8) or mice receiving oral captopril (0.688 mg/ml captopril in the drinking water for 6 weeks, N=10). HRV results for linear and non-linear parameters were attenuated following chronic captopril for 6 weeks compared to control. Captopril was associated with a trend for an increase in average heart rate and approximate entropy (ApEn), a non-linear measure of HRV decreased significantly compared to control (p
UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18606470
UR - https://www.scopus.com/pages/publications/67650718374
M3 - Article
SN - 0167-5273
VL - 136
SP - 211
EP - 213
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 2
ER -