Chronic extra-aortic balloon counterpulsation: First-in-human pilot study in end-stage heart failure

Christopher Hayward, William Peters, Alan Merry, Peter Ruygrok, Paul Jansz, Gerry O'Driscoll, Robert Larbalestier, Julian Smith, Betty Ho, Malcolm Legget, F Paget Milsom

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24 Citations (Scopus)


BACKGROUND: Some patients continue to have significant heart failure symptoms despite optimal medical therapy. METHODS: We describe a first-in-human experience with an implantable non-blood-contacting extra-ascending aortic counterpulsation heart assist system (C-Pulse) in 5 end-stage heart failure patients, aged 54 to 73 years. RESULTS: All patients improved by 1 NYHA class and improvements in invasive hemodynamics were documented in 3 patients. Three of 5 patients (60 ) had infectious complications. Two patients were explanted at 5 and 7 weeks, respectively, as a result of mediastinal infection related to the implant procedure. One patient was successfully transplanted at 1 month and 1 remained hemodynamically improved on the device at 6 months but suffered infective complications. The device and protocol have been modified as a result of this pilot study with a further multicenter safety study underway.
Original languageEnglish
Pages (from-to)1427 - 1432
Number of pages6
JournalThe Journal of Heart and Lung Transplantation
Issue number12
Publication statusPublished - 2010

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