Abstract
Objective: To determine whether 6 weeks continuous treatment with an angiotensin converting enzyme (ACE) inhibitor reduced renal vascular responsiveness in vivo, since this treatment results in extensive phenotypic conversion of afferent arteriolar cells from contractile to endocrine-like, renin secretory cells. Methods: Enalapril (10 μg/kg per h s.c.) was delivered continuously for 6 weeks. In anaesthetized rabbits (treated or sham), arterial blood pressure and renal blood flow were measured and renal responsiveness tested by constructing dose-response curves to bolus doses of phenylephrine, angiotensin II and acetylcholine delivered directly into the renal artery. Results: ACE inhibition resulted in a significant shift to the left in the renal vascular conductance responses to acetylcholine (P <0.005) and angiotensin II (P <0.05), indicating enhanced, not reduced, responsiveness to these agents. There were no significant effects of chronic ACE inhibition on the conductance responses to phenylephrine. Conclusions: Contrary to our hypothesis, 6 weeks ACE inhibition did not reduce renal vascular responsiveness to three vasoactive agents, suggesting that the phenotypic changes observed in the afferent arterioles and to a lesser extent the interlobular arteries, were either insignificant or compensated for by other changes in renal circulatory control.
| Original language | English |
|---|---|
| Pages (from-to) | 1497-1503 |
| Number of pages | 7 |
| Journal | Journal of Hypertension |
| Volume | 19 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2001 |
Keywords
- Afferent arteriole
- Kidney
- Morphology
- Renal vascular resistance
- Renin
Cite this
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Chronic angiotensin converting enzyme inhibition enhances renal vascular responsiveness to acetylcholine in anaesthetized rabbits. / Denton, Kate M.; Lamden, Melanie; Shweta, Amany; Alcorn, Daine; Anderson, Warwick P.
In: Journal of Hypertension, Vol. 19, No. 8, 2001, p. 1497-1503.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Chronic angiotensin converting enzyme inhibition enhances renal vascular responsiveness to acetylcholine in anaesthetized rabbits
AU - Denton, Kate M.
AU - Lamden, Melanie
AU - Shweta, Amany
AU - Alcorn, Daine
AU - Anderson, Warwick P.
PY - 2001
Y1 - 2001
N2 - Objective: To determine whether 6 weeks continuous treatment with an angiotensin converting enzyme (ACE) inhibitor reduced renal vascular responsiveness in vivo, since this treatment results in extensive phenotypic conversion of afferent arteriolar cells from contractile to endocrine-like, renin secretory cells. Methods: Enalapril (10 μg/kg per h s.c.) was delivered continuously for 6 weeks. In anaesthetized rabbits (treated or sham), arterial blood pressure and renal blood flow were measured and renal responsiveness tested by constructing dose-response curves to bolus doses of phenylephrine, angiotensin II and acetylcholine delivered directly into the renal artery. Results: ACE inhibition resulted in a significant shift to the left in the renal vascular conductance responses to acetylcholine (P <0.005) and angiotensin II (P <0.05), indicating enhanced, not reduced, responsiveness to these agents. There were no significant effects of chronic ACE inhibition on the conductance responses to phenylephrine. Conclusions: Contrary to our hypothesis, 6 weeks ACE inhibition did not reduce renal vascular responsiveness to three vasoactive agents, suggesting that the phenotypic changes observed in the afferent arterioles and to a lesser extent the interlobular arteries, were either insignificant or compensated for by other changes in renal circulatory control.
AB - Objective: To determine whether 6 weeks continuous treatment with an angiotensin converting enzyme (ACE) inhibitor reduced renal vascular responsiveness in vivo, since this treatment results in extensive phenotypic conversion of afferent arteriolar cells from contractile to endocrine-like, renin secretory cells. Methods: Enalapril (10 μg/kg per h s.c.) was delivered continuously for 6 weeks. In anaesthetized rabbits (treated or sham), arterial blood pressure and renal blood flow were measured and renal responsiveness tested by constructing dose-response curves to bolus doses of phenylephrine, angiotensin II and acetylcholine delivered directly into the renal artery. Results: ACE inhibition resulted in a significant shift to the left in the renal vascular conductance responses to acetylcholine (P <0.005) and angiotensin II (P <0.05), indicating enhanced, not reduced, responsiveness to these agents. There were no significant effects of chronic ACE inhibition on the conductance responses to phenylephrine. Conclusions: Contrary to our hypothesis, 6 weeks ACE inhibition did not reduce renal vascular responsiveness to three vasoactive agents, suggesting that the phenotypic changes observed in the afferent arterioles and to a lesser extent the interlobular arteries, were either insignificant or compensated for by other changes in renal circulatory control.
KW - Afferent arteriole
KW - Kidney
KW - Morphology
KW - Renal vascular resistance
KW - Renin
UR - http://www.scopus.com/inward/record.url?scp=0034909068&partnerID=8YFLogxK
U2 - 10.1097/00004872-200108000-00019
DO - 10.1097/00004872-200108000-00019
M3 - Article
VL - 19
SP - 1497
EP - 1503
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
IS - 8
ER -