Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family

Gino R. Somers, Fleur Hammet, Erica Woollatt, Robert I. Richards, Melissa C. Southey, Deon J. Venter

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

The G-protein-coupled P2Y purinoceptors mediate a variety of physiological effects in response to extracellular nucleotides. With the recent discovery of several new members from a variety of species, the P2Y purinoceptor family now encompasses types P2Y1 to P2Y8. By fluorescence in situ hybridization and utilization of the National Center for Biotechnology Information (NCBI) database, the human P2Y6 gene was localized to chromosome 11q13.5, between polymorphic markers D11S1314 and D11S916. NCBI database analysis of the remaining human P2Y purinoceptor genes revealed that P2Y2 and P2Y6 mapped to within less than 4 cM, and thus constitute the first described chromosomal clustering of this gene family. Phylogenetic analysis of the P2Y purinoceptor family demonstrated the presence of five evolutionary branches and suggests the occurrence of an ancient gene duplication event.

Original languageEnglish
Pages (from-to)127-130
Number of pages4
JournalGenomics
Volume44
Issue number1
DOIs
Publication statusPublished - 15 Aug 1997
Externally publishedYes

Cite this