Chromatin modifications associated with diabetes

Samuel T Keating, Assam El-Osta

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24 Citations (Scopus)


Accelerated rates of vascular complications are associated with diabetes mellitus. Environmental factors including hyperglycaemia contribute to the progression of diabetic complications. Epidemiological and experimental animal studies identified poor glycaemic control as a major contributor to the development of complications. These studies suggest that early exposure to hyperglycaemia can instigate the development of complications that present later in the progression of the disease, despite improved glycaemic control. Recent experiments reveal a striking commonality associated with gene-activating hyperglycaemic events and chromatin modification. The best characterised to date are associated with the chemical changes of amino-terminal tails of histone H3. Enzymes that write specified histone tail modifications are not well understood in models of hyperglycaemia and metabolic memory as well as human diabetes. The best-characterised enzyme is the lysine specific Set7 methyltransferase. The contribution of Set7 to the aetiology of diabetic complications may extend to other transcriptional events through methylation of non-histone substrates.
Original languageEnglish
Pages (from-to)399-412
Number of pages14
JournalJournal of Cardiovascular Translational Research
Issue number4
Publication statusPublished - 2012


  • Diabetic complications
  • Diabetes
  • Epigenetic gene regulation
  • Set7 methyltransferase
  • Hyperglycaemia
  • Histone methylation
  • Metabolic memory
  • DNA methylation
  • Histone acetylation

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