Chromatin Architecture and the Generation of Antigen Receptor Diversity

Suchit Jhunjhunwala, Menno C. van Zelm, Mandy M. Peak, Cornelis Murre

Research output: Contribution to journalReview ArticleResearchpeer-review

96 Citations (Scopus)

Abstract

The adaptive immune system generates a specific response to a vast spectrum of antigens. This remarkable property is achieved by lymphocytes that each express single and unique antigen receptors. During lymphocyte development, antigen receptor coding elements are assembled from widely dispersed gene segments. The assembly of antigen receptors is controlled at multiple levels, including epigenetic marking, nuclear location, and chromatin topology. Here, we review recently uncovered mechanisms that underpin long-range genomic interactions and the generation of antigen receptor diversity.

Original languageEnglish
Pages (from-to)435-448
Number of pages14
JournalCell
Volume138
Issue number3
DOIs
Publication statusPublished - 7 Aug 2009
Externally publishedYes

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