TY - JOUR
T1 - Cholinesterase inhibitory activity and chemical constituents of Stenochlaena palustris fronds at two different stages of maturity
AU - Chear, Nelson Jeng Yeou
AU - Khaw, Kooi Yeong
AU - Murugaiyah, Vikneswaran
AU - Lai, Choon Sheen
N1 - Funding Information:
This study was supported by Universiti Sains Malaysia under the Short-term Grant ( 304/CDADAH/6311104 ) and Research University Grant ( 1001/CDADAH/815096 ). NJYC is a recipient of the MyBrain scholarship funded by the Ministry of Education , Malaysia.
Publisher Copyright:
Copyright © 2016, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/4
Y1 - 2016/4
N2 - Stenochlaena palustris fronds are popular as a vegetable in Southeast Asia. The objectives of this study were to evaluate the anticholinesterase properties and phytochemical profiles of the young and mature fronds of this plant. Both types of fronds were found to have selective inhibitory effect against butyrylcholinesterase compared with acetylcholinesterase. However, different sets of compounds were responsible for their activity. In young fronds, an antibutyrylcholinesterase effect was observed in the hexane extract, which was comprised of a variety of aliphatic hydrocarbons, fatty acids, and phytosterols. In the mature fronds, inhibitory activity was observed in the methanol extract, which contained a series of kaempferol glycosides. Our results provided novel information concerning the ability of S. palustris to inhibit cholinesterase and its phytochemical profile. Further research to investigate the potential use of this plant against Alzheimer's disease is warranted, however, young and mature fronds should be distinguished due to their phytochemical differences.
AB - Stenochlaena palustris fronds are popular as a vegetable in Southeast Asia. The objectives of this study were to evaluate the anticholinesterase properties and phytochemical profiles of the young and mature fronds of this plant. Both types of fronds were found to have selective inhibitory effect against butyrylcholinesterase compared with acetylcholinesterase. However, different sets of compounds were responsible for their activity. In young fronds, an antibutyrylcholinesterase effect was observed in the hexane extract, which was comprised of a variety of aliphatic hydrocarbons, fatty acids, and phytosterols. In the mature fronds, inhibitory activity was observed in the methanol extract, which contained a series of kaempferol glycosides. Our results provided novel information concerning the ability of S. palustris to inhibit cholinesterase and its phytochemical profile. Further research to investigate the potential use of this plant against Alzheimer's disease is warranted, however, young and mature fronds should be distinguished due to their phytochemical differences.
KW - anticholinesterase
KW - Blechnaceae
KW - frond maturity
KW - phytochemical profile
KW - Stenochlaena palustris
UR - http://www.scopus.com/inward/record.url?scp=84960362290&partnerID=8YFLogxK
U2 - 10.1016/j.jfda.2015.12.005
DO - 10.1016/j.jfda.2015.12.005
M3 - Article
C2 - 28911590
AN - SCOPUS:84960362290
VL - 24
SP - 358
EP - 366
JO - Journal of Food and Drug Analysis
JF - Journal of Food and Drug Analysis
SN - 1021-9498
IS - 2
ER -