Cholinesterase inhibition activity and molecular docking study of Eugenol derivatives

Khairunisa Mohd Zamli, Asnuzilawati Asari, Kooi Yeong Khaw, Vikneswaran Murugaiyah, Mariya Al-Rashida, Habsah Mohamad, Hanis Mohd Yusoff, Nurul Huda Abdul Wahab, Hasnah Osman

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    The study was conducted to explore the anticholinesterase inhibition property of eugenol derived molecules. Ten eugenol derivatives were synthesized and evaluated for the inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by Ellman’s method. Most of the tested derivatives showed higher inhibition on BChE than AChE, however, their overall inhibitory activity was weak. In contrast, three derivatives (compounds 3,6,9) showed higher and good AChE inhibitory activity of more than 50% inhibition at 10 µg/mL. Among them, compound 9 bearing a ethyl substituent at para position of the benzoyl ring showed the most potent AChE inhibition, with IC50 of 5.64 µg/mL. Ligand-protein docking simulation was also performed for the most active derived molecules (compounds 3,6,9).

    Original languageEnglish
    Pages (from-to)1037-1045
    Number of pages9
    JournalSains Malaysiana
    Volume50
    Issue number4
    DOIs
    Publication statusPublished - Apr 2021

    Keywords

    • Acetylcholinesterase
    • Butyrylcholinesterase
    • Eugenol derivatives
    • Molecular docking

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