Choline ionic liquid enhances the stability of Herceptin® (trastuzumab)

Mouhamad Reslan; Vijayaraghavan Ranganathan; Douglas R. Macfarlane; Veysel Kayser

doi:10.1039/c8cc06397d

Choline ionic liquid enhances the stability of Herceptin® (trastuzumab)

Mouhamad Reslan, Vijayaraghavan Ranganathan, Douglas R. Macfarlane, Veysel Kayser

School of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

34 Citations (Scopus)

Abstract

We investigated the effect of an emerging biocompatible ionic liquid, choline dihydrogen phosphate (CDHP), on the stability of high-concentration formulations of Herceptin® (trastuzumab). Our results show that CDHP significantly suppresses unfolding and aggregation of trastuzumab, demonstrating great promise as an additive in the development of stable therapeutic antibody formulations.

Original language	English
Pages (from-to)	10622-10625
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	75
DOIs	https://doi.org/10.1039/c8cc06397d
Publication status	Published - 28 Aug 2018

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abstract = "We investigated the effect of an emerging biocompatible ionic liquid, choline dihydrogen phosphate (CDHP), on the stability of high-concentration formulations of Herceptin{\textregistered} (trastuzumab). Our results show that CDHP significantly suppresses unfolding and aggregation of trastuzumab, demonstrating great promise as an additive in the development of stable therapeutic antibody formulations.",

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AU - Ranganathan, Vijayaraghavan

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AU - Kayser, Veysel

PY - 2018/8/28

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AB - We investigated the effect of an emerging biocompatible ionic liquid, choline dihydrogen phosphate (CDHP), on the stability of high-concentration formulations of Herceptin® (trastuzumab). Our results show that CDHP significantly suppresses unfolding and aggregation of trastuzumab, demonstrating great promise as an additive in the development of stable therapeutic antibody formulations.

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JO - Chemical Communications

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Choline ionic liquid enhances the stability of Herceptin® (trastuzumab)

Abstract

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