Choline ionic liquid enhances the stability of Herceptin® (trastuzumab)

Mouhamad Reslan, Vijayaraghavan Ranganathan, Douglas R. Macfarlane, Veysel Kayser

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

We investigated the effect of an emerging biocompatible ionic liquid, choline dihydrogen phosphate (CDHP), on the stability of high-concentration formulations of Herceptin® (trastuzumab). Our results show that CDHP significantly suppresses unfolding and aggregation of trastuzumab, demonstrating great promise as an additive in the development of stable therapeutic antibody formulations.

Original languageEnglish
Pages (from-to)10622-10625
Number of pages4
JournalChemical Communications
Volume54
Issue number75
DOIs
Publication statusPublished - 28 Aug 2018

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