Choline ionic liquid enhances the stability of Herceptin® (trastuzumab)

Mouhamad Reslan, Vijayaraghavan Ranganathan, Douglas R. Macfarlane, Veysel Kayser

Research output: Contribution to journalArticleResearchpeer-review

Abstract

We investigated the effect of an emerging biocompatible ionic liquid, choline dihydrogen phosphate (CDHP), on the stability of high-concentration formulations of Herceptin® (trastuzumab). Our results show that CDHP significantly suppresses unfolding and aggregation of trastuzumab, demonstrating great promise as an additive in the development of stable therapeutic antibody formulations.

Original languageEnglish
Pages (from-to)10622-10625
Number of pages4
JournalChemical Communications
Volume54
Issue number75
DOIs
Publication statusPublished - 28 Aug 2018

Cite this

Reslan, Mouhamad ; Ranganathan, Vijayaraghavan ; Macfarlane, Douglas R. ; Kayser, Veysel. / Choline ionic liquid enhances the stability of Herceptin® (trastuzumab). In: Chemical Communications. 2018 ; Vol. 54, No. 75. pp. 10622-10625.
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Choline ionic liquid enhances the stability of Herceptin® (trastuzumab). / Reslan, Mouhamad; Ranganathan, Vijayaraghavan; Macfarlane, Douglas R.; Kayser, Veysel.

In: Chemical Communications, Vol. 54, No. 75, 28.08.2018, p. 10622-10625.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Ranganathan, Vijayaraghavan

AU - Macfarlane, Douglas R.

AU - Kayser, Veysel

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