Cholesterol reduction and artery compliance in hypertension

Kathryn E. Ferrier, Michael H. Muhlmann, Jean Philippe Baguet, James D. Cameron, Garry L. Jennings, Anthony M. Dart, Bronwyn A. Kingwell

Research output: Contribution to journalShort SurveyResearchpeer-review

1 Citation (Scopus)

Abstract

Large artery stiffening, which has been independently related to cardiovascular mortality, is the primary cause of isolated systolic hypertension. We studied normocholesterolemic patients with stage I isolated systolic hypertension who took a placebo for 3 months and 80 mg of atorvastatin daily for 3 months in a randomized order. Atorvastatin increased large artery compliance and reduced systolic, mean, and diastolic blood pressure. Through a reduction in large artery stiffness, HMG-CoA reductase inhibitor (statin) therapy may be effective for the treatment of normolipidemic patients with isolated systolic hypertension.

Original languageEnglish
Pages (from-to)14-16
Number of pages3
JournalCardiology Review
Volume19
Issue number14
Publication statusPublished - Dec 2002
Externally publishedYes

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