Large artery stiffening, which has been independently related to cardiovascular mortality, is the primary cause of isolated systolic hypertension. We studied normocholesterolemic patients with stage I isolated systolic hypertension who took a placebo for 3 months and 80 mg of atorvastatin daily for 3 months in a randomized order. Atorvastatin increased large artery compliance and reduced systolic, mean, and diastolic blood pressure. Through a reduction in large artery stiffness, HMG-CoA reductase inhibitor (statin) therapy may be effective for the treatment of normolipidemic patients with isolated systolic hypertension.
|Number of pages||3|
|Publication status||Published - Dec 2002|