Cholesterol Levels Are Associated with 30-day Mortality from Ischemic Stroke in Dialysis Patients

I. Kuan Wang, Chung Hsiang Liu, Tzung Hai Yen, Jiann Shing Jeng, Shih Pin Hsu, Chih Hung Chen, Li Ming Lien, Ruey Tay Lin, An Chih Chen, Huey Juan Lin, Hsin Yi Chi, Ta Chang Lai, Yu Sun, Siu Pak Lee, Sheng Feng Sung, Po Lin Chen, Jiunn Tay Lee, Tsuey Ru Chiang, Shinn Kuang Lin, Chih Hsin MuoHenry Ma, Chi Pang Wen, Fung Chang Sung, Chung Y. Hsu, Taiwan Stroke Registry Investigators

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Abstract

Background We investigated the impact of serum cholesterol levels on 30-day mortality after ischemic stroke in dialysis patients. Methods From the Taiwan Stroke Registry data, we identified 46,770 ischemic stroke cases, including 1101 dialysis patients and 45,669 nondialysis patients from 2006 to 2013. Results Overall, the 30-day mortality was 1.46-fold greater in the dialysis group than in the nondialysis group (1.75 versus 1.20 per 1000 person-days). The mortality rates were 1.64, .62, 2.82, and 2.23 per 1000 person-days in dialysis patients with serum total cholesterol levels of <120 mg/dL, 120-159 mg/dL, 160-199 mg/dL, and ≥200 mg/dL, respectively. Compared to dialysis patients with serum total cholesterol levels of 120-159 mg/dL, the corresponding adjusted hazard ratios of mortality were 4.20 (95% confidence interval [CI] = 1.01-17.4), 8.06 (95% CI = 2.02-32.2), and 6.89 (95% CI = 1.59-29.8) for those with cholesterol levels of <120 mg/dL, 160-199 mg/dL, and ≥200 mg/dL, respectively. Conclusions Dialysis patients with serum total cholesterol levels of ≥160 mg/dL or <120 mg/dL on admission are at an elevated hazard of 30-day mortality after ischemic stroke.

Original languageEnglish
Pages (from-to)1349-1356
Number of pages8
JournalJournal of Stroke and Cerebrovascular Diseases
Volume26
Issue number6
DOIs
Publication statusPublished - 1 Jun 2017

Keywords

  • Cholesterol
  • dialysis
  • ischemic stroke, mortality
  • prognosis

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