Chlamydia trachomatis incidence and re-infection among young women - behavioural and microbiological characteristics

Jennifer Walker, Sepehr Tabrizi, Christopher Kit Fairley, Marcus Y Chen, Catriona Bradshaw, Jimmy Twin, Nicole Taylor, Basil Donovan, John M Kaldor, Kathleen McNamee, Eve Urban, Sandra Walker, Marian Currie, Hudson Birden, Francis J Bowden, Jane Gunn, Marie Pirotta, Lyle C Gurrin, Veerakathy Harindra, Suzanne M Garland & 1 others Jane Hocking

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Abstract

Background: This study aimed to estimate rates of chlamydia incidence and re-infection and to investigate the dynamics of chlamydia organism load in prevalent, incident and re-infections among young Australian women. Methods: 1,116 women aged 16 to 25 years were recruited from primary care clinics in Australia. Vaginal swabs were collected at 3 to 6 month intervals for chlamydia testing. Chlamydia organism load was measured by quantitative PCR. Results: There were 47 incident cases of chlamydia diagnosed and 1,056.34 person years of follow up with a rate of 4.4 per 100 person years (95 CI: 3.3, 5.9). Incident infection was associated with being aged 16 to 20 years [RR = 3.7 (95 CI: 1.9, 7.1)], being employed [RR = 2.4 (95 CI: 1.1, 4.9)] and having two or more new sex partners [RR = 5.5 (95 CI: 2.6, 11.7)]. Recent antibiotic use was associated with a reduced incidence [RR:0.1 (95 CI: 0.0, 0.5)]. There were 14 re-infections with a rate of 22.3 per 100 person years (95 CI: 13.2, 37.6). The median time to re-infection was 4.6 months. Organism load was higher for prevalent than incident infections (p
Original languageEnglish
Article numbere37778
Number of pages9
JournalPLoS ONE
Volume7
Issue number5
DOIs
Publication statusPublished - 2012

Cite this

Walker, Jennifer ; Tabrizi, Sepehr ; Fairley, Christopher Kit ; Chen, Marcus Y ; Bradshaw, Catriona ; Twin, Jimmy ; Taylor, Nicole ; Donovan, Basil ; Kaldor, John M ; McNamee, Kathleen ; Urban, Eve ; Walker, Sandra ; Currie, Marian ; Birden, Hudson ; Bowden, Francis J ; Gunn, Jane ; Pirotta, Marie ; Gurrin, Lyle C ; Harindra, Veerakathy ; Garland, Suzanne M ; Hocking, Jane. / Chlamydia trachomatis incidence and re-infection among young women - behavioural and microbiological characteristics. In: PLoS ONE. 2012 ; Vol. 7, No. 5.
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title = "Chlamydia trachomatis incidence and re-infection among young women - behavioural and microbiological characteristics",
abstract = "Background: This study aimed to estimate rates of chlamydia incidence and re-infection and to investigate the dynamics of chlamydia organism load in prevalent, incident and re-infections among young Australian women. Methods: 1,116 women aged 16 to 25 years were recruited from primary care clinics in Australia. Vaginal swabs were collected at 3 to 6 month intervals for chlamydia testing. Chlamydia organism load was measured by quantitative PCR. Results: There were 47 incident cases of chlamydia diagnosed and 1,056.34 person years of follow up with a rate of 4.4 per 100 person years (95 CI: 3.3, 5.9). Incident infection was associated with being aged 16 to 20 years [RR = 3.7 (95 CI: 1.9, 7.1)], being employed [RR = 2.4 (95 CI: 1.1, 4.9)] and having two or more new sex partners [RR = 5.5 (95 CI: 2.6, 11.7)]. Recent antibiotic use was associated with a reduced incidence [RR:0.1 (95 CI: 0.0, 0.5)]. There were 14 re-infections with a rate of 22.3 per 100 person years (95 CI: 13.2, 37.6). The median time to re-infection was 4.6 months. Organism load was higher for prevalent than incident infections (p",
author = "Jennifer Walker and Sepehr Tabrizi and Fairley, {Christopher Kit} and Chen, {Marcus Y} and Catriona Bradshaw and Jimmy Twin and Nicole Taylor and Basil Donovan and Kaldor, {John M} and Kathleen McNamee and Eve Urban and Sandra Walker and Marian Currie and Hudson Birden and Bowden, {Francis J} and Jane Gunn and Marie Pirotta and Gurrin, {Lyle C} and Veerakathy Harindra and Garland, {Suzanne M} and Jane Hocking",
year = "2012",
doi = "10.1371/journal.pone.0037778",
language = "English",
volume = "7",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
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Walker, J, Tabrizi, S, Fairley, CK, Chen, MY, Bradshaw, C, Twin, J, Taylor, N, Donovan, B, Kaldor, JM, McNamee, K, Urban, E, Walker, S, Currie, M, Birden, H, Bowden, FJ, Gunn, J, Pirotta, M, Gurrin, LC, Harindra, V, Garland, SM & Hocking, J 2012, 'Chlamydia trachomatis incidence and re-infection among young women - behavioural and microbiological characteristics', PLoS ONE, vol. 7, no. 5, e37778. https://doi.org/10.1371/journal.pone.0037778

Chlamydia trachomatis incidence and re-infection among young women - behavioural and microbiological characteristics. / Walker, Jennifer; Tabrizi, Sepehr; Fairley, Christopher Kit; Chen, Marcus Y; Bradshaw, Catriona; Twin, Jimmy; Taylor, Nicole; Donovan, Basil; Kaldor, John M; McNamee, Kathleen; Urban, Eve; Walker, Sandra; Currie, Marian; Birden, Hudson; Bowden, Francis J; Gunn, Jane; Pirotta, Marie; Gurrin, Lyle C; Harindra, Veerakathy; Garland, Suzanne M; Hocking, Jane.

In: PLoS ONE, Vol. 7, No. 5, e37778, 2012.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Chlamydia trachomatis incidence and re-infection among young women - behavioural and microbiological characteristics

AU - Walker, Jennifer

AU - Tabrizi, Sepehr

AU - Fairley, Christopher Kit

AU - Chen, Marcus Y

AU - Bradshaw, Catriona

AU - Twin, Jimmy

AU - Taylor, Nicole

AU - Donovan, Basil

AU - Kaldor, John M

AU - McNamee, Kathleen

AU - Urban, Eve

AU - Walker, Sandra

AU - Currie, Marian

AU - Birden, Hudson

AU - Bowden, Francis J

AU - Gunn, Jane

AU - Pirotta, Marie

AU - Gurrin, Lyle C

AU - Harindra, Veerakathy

AU - Garland, Suzanne M

AU - Hocking, Jane

PY - 2012

Y1 - 2012

N2 - Background: This study aimed to estimate rates of chlamydia incidence and re-infection and to investigate the dynamics of chlamydia organism load in prevalent, incident and re-infections among young Australian women. Methods: 1,116 women aged 16 to 25 years were recruited from primary care clinics in Australia. Vaginal swabs were collected at 3 to 6 month intervals for chlamydia testing. Chlamydia organism load was measured by quantitative PCR. Results: There were 47 incident cases of chlamydia diagnosed and 1,056.34 person years of follow up with a rate of 4.4 per 100 person years (95 CI: 3.3, 5.9). Incident infection was associated with being aged 16 to 20 years [RR = 3.7 (95 CI: 1.9, 7.1)], being employed [RR = 2.4 (95 CI: 1.1, 4.9)] and having two or more new sex partners [RR = 5.5 (95 CI: 2.6, 11.7)]. Recent antibiotic use was associated with a reduced incidence [RR:0.1 (95 CI: 0.0, 0.5)]. There were 14 re-infections with a rate of 22.3 per 100 person years (95 CI: 13.2, 37.6). The median time to re-infection was 4.6 months. Organism load was higher for prevalent than incident infections (p

AB - Background: This study aimed to estimate rates of chlamydia incidence and re-infection and to investigate the dynamics of chlamydia organism load in prevalent, incident and re-infections among young Australian women. Methods: 1,116 women aged 16 to 25 years were recruited from primary care clinics in Australia. Vaginal swabs were collected at 3 to 6 month intervals for chlamydia testing. Chlamydia organism load was measured by quantitative PCR. Results: There were 47 incident cases of chlamydia diagnosed and 1,056.34 person years of follow up with a rate of 4.4 per 100 person years (95 CI: 3.3, 5.9). Incident infection was associated with being aged 16 to 20 years [RR = 3.7 (95 CI: 1.9, 7.1)], being employed [RR = 2.4 (95 CI: 1.1, 4.9)] and having two or more new sex partners [RR = 5.5 (95 CI: 2.6, 11.7)]. Recent antibiotic use was associated with a reduced incidence [RR:0.1 (95 CI: 0.0, 0.5)]. There were 14 re-infections with a rate of 22.3 per 100 person years (95 CI: 13.2, 37.6). The median time to re-infection was 4.6 months. Organism load was higher for prevalent than incident infections (p

UR - http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037778

U2 - 10.1371/journal.pone.0037778

DO - 10.1371/journal.pone.0037778

M3 - Article

VL - 7

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 5

M1 - e37778

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