Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice

Malcolm R Starkey, Richard Y Kim, Emma L Beckett, Heidi C Schilter, Doris SC Shim, Ama-Tawiah Essilfie, Duc H Nguyen, Kenneth W Beagley, Joerg Mattes, Charles R Mackay, Jay C Horvat, Philip M Hansbro

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    Abstract

    BACKGROUND: Viral and bacterial respiratory tract infections in early-life are linked to the development of allergic airway inflammation and asthma. However, the mechanisms involved are not well understood. We have previously shown that neonatal and infant, but not adult, chlamydial lung infections in mice permanently alter inflammatory phenotype and physiology to increase the severity of allergic airway disease by increasing lung interleukin (IL)-13 expression, mucus hyper-secretion and airway hyper-responsiveness. This occurred through different mechanisms with infection at different ages. Neonatal infection suppressed inflammatory responses but enhanced systemic dendritic cell:T-cell IL-13 release and induced permanent alterations in lung structure (i.e., increased the size of alveoli). Infant infection enhanced inflammatory responses but had no effect on lung structure. Here we investigated the role of hematopoietic cells in these processes using bone marrow chimera studies. METHODOLOGY/PRINCIPAL FINDINGS: Neonatal (
    Original languageEnglish
    Article numbere42588
    Number of pages7
    JournalPLoS ONE
    Volume7
    Issue number8
    DOIs
    Publication statusPublished - 2012

    Cite this

    Starkey, M. R., Kim, R. Y., Beckett, E. L., Schilter, H. C., Shim, D. SC., Essilfie, A-T., ... Hansbro, P. M. (2012). Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice. PLoS ONE, 7(8), [e42588]. https://doi.org/10.1371/journal.pone.0042588
    Starkey, Malcolm R ; Kim, Richard Y ; Beckett, Emma L ; Schilter, Heidi C ; Shim, Doris SC ; Essilfie, Ama-Tawiah ; Nguyen, Duc H ; Beagley, Kenneth W ; Mattes, Joerg ; Mackay, Charles R ; Horvat, Jay C ; Hansbro, Philip M. / Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice. In: PLoS ONE. 2012 ; Vol. 7, No. 8.
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    title = "Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice",
    abstract = "BACKGROUND: Viral and bacterial respiratory tract infections in early-life are linked to the development of allergic airway inflammation and asthma. However, the mechanisms involved are not well understood. We have previously shown that neonatal and infant, but not adult, chlamydial lung infections in mice permanently alter inflammatory phenotype and physiology to increase the severity of allergic airway disease by increasing lung interleukin (IL)-13 expression, mucus hyper-secretion and airway hyper-responsiveness. This occurred through different mechanisms with infection at different ages. Neonatal infection suppressed inflammatory responses but enhanced systemic dendritic cell:T-cell IL-13 release and induced permanent alterations in lung structure (i.e., increased the size of alveoli). Infant infection enhanced inflammatory responses but had no effect on lung structure. Here we investigated the role of hematopoietic cells in these processes using bone marrow chimera studies. METHODOLOGY/PRINCIPAL FINDINGS: Neonatal (",
    author = "Starkey, {Malcolm R} and Kim, {Richard Y} and Beckett, {Emma L} and Schilter, {Heidi C} and Shim, {Doris SC} and Ama-Tawiah Essilfie and Nguyen, {Duc H} and Beagley, {Kenneth W} and Joerg Mattes and Mackay, {Charles R} and Horvat, {Jay C} and Hansbro, {Philip M}",
    year = "2012",
    doi = "10.1371/journal.pone.0042588",
    language = "English",
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    Starkey, MR, Kim, RY, Beckett, EL, Schilter, HC, Shim, DSC, Essilfie, A-T, Nguyen, DH, Beagley, KW, Mattes, J, Mackay, CR, Horvat, JC & Hansbro, PM 2012, 'Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice', PLoS ONE, vol. 7, no. 8, e42588. https://doi.org/10.1371/journal.pone.0042588

    Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice. / Starkey, Malcolm R; Kim, Richard Y; Beckett, Emma L; Schilter, Heidi C; Shim, Doris SC; Essilfie, Ama-Tawiah; Nguyen, Duc H; Beagley, Kenneth W; Mattes, Joerg; Mackay, Charles R; Horvat, Jay C; Hansbro, Philip M.

    In: PLoS ONE, Vol. 7, No. 8, e42588, 2012.

    Research output: Contribution to journalArticleResearchpeer-review

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    T1 - Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice

    AU - Starkey, Malcolm R

    AU - Kim, Richard Y

    AU - Beckett, Emma L

    AU - Schilter, Heidi C

    AU - Shim, Doris SC

    AU - Essilfie, Ama-Tawiah

    AU - Nguyen, Duc H

    AU - Beagley, Kenneth W

    AU - Mattes, Joerg

    AU - Mackay, Charles R

    AU - Horvat, Jay C

    AU - Hansbro, Philip M

    PY - 2012

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    N2 - BACKGROUND: Viral and bacterial respiratory tract infections in early-life are linked to the development of allergic airway inflammation and asthma. However, the mechanisms involved are not well understood. We have previously shown that neonatal and infant, but not adult, chlamydial lung infections in mice permanently alter inflammatory phenotype and physiology to increase the severity of allergic airway disease by increasing lung interleukin (IL)-13 expression, mucus hyper-secretion and airway hyper-responsiveness. This occurred through different mechanisms with infection at different ages. Neonatal infection suppressed inflammatory responses but enhanced systemic dendritic cell:T-cell IL-13 release and induced permanent alterations in lung structure (i.e., increased the size of alveoli). Infant infection enhanced inflammatory responses but had no effect on lung structure. Here we investigated the role of hematopoietic cells in these processes using bone marrow chimera studies. METHODOLOGY/PRINCIPAL FINDINGS: Neonatal (

    AB - BACKGROUND: Viral and bacterial respiratory tract infections in early-life are linked to the development of allergic airway inflammation and asthma. However, the mechanisms involved are not well understood. We have previously shown that neonatal and infant, but not adult, chlamydial lung infections in mice permanently alter inflammatory phenotype and physiology to increase the severity of allergic airway disease by increasing lung interleukin (IL)-13 expression, mucus hyper-secretion and airway hyper-responsiveness. This occurred through different mechanisms with infection at different ages. Neonatal infection suppressed inflammatory responses but enhanced systemic dendritic cell:T-cell IL-13 release and induced permanent alterations in lung structure (i.e., increased the size of alveoli). Infant infection enhanced inflammatory responses but had no effect on lung structure. Here we investigated the role of hematopoietic cells in these processes using bone marrow chimera studies. METHODOLOGY/PRINCIPAL FINDINGS: Neonatal (

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