Chlamydia Infection Between Men and Women

A Cross-Sectional Study of Heterosexual Partnerships

Sarah Huffam, Eric Pui Fung Chow, Charussri Leeyaphan, Christopher K Fairley, Jane Hocking, Samuel Phillips, Sepehr Tabrizi, Clare Bellhouse, Catriona S. Bradshaw, Glenda Fehler, Suzanne Garland, Marcus Y. Chen

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background
Studies of sexual partnerships can further our understanding of the sexual transmission of chlamydia, which is important for informing public health interventions and clinical management. The aim of this study was to ascertain among heterosexual dyads the proportion concordantly infected with chlamydia and factors associated with infection between partners.

Methods
This study was conducted at the Melbourne Sexual Health Centre between January 2006 and March 2015. Heterosexual partners attending the clinic on the same day were identified prospectively. Dyads where 1 or both individuals were diagnosed with chlamydia by a test performed on the day of joint attendance or within the prior 30 days were included. Testing was by strand displacement assay. Men and women with genital symptoms underwent clinical examination.

Results
Of 233 females with chlamydia, 76% (n = 178) of their male partners tested positive. Of the chlamydia-positive females with cervicitis, 91% of males were chlamydia positive. Male infection was less likely if their partner had taken azithromycin or doxycycline within 30 days (7% vs 25%; P = .039). Of 235 males with chlamydia, 77% (n = 178) of their female partners tested positive. No associations were found between male symptoms, signs, or recent antibiotic use and a positive chlamydia result in female partners. Sixty-one percent of the dyads were concordantly infected with chlamydia.

Conclusions
These results underscore the high likelihood of heterosexual partners of men and women with chlamydia being infected and the importance that partners are tested and managed appropriately for chlamydia.
Original languageEnglish
Article numberofx160
Number of pages6
JournalOpen Forum Infectious Diseases
Volume4
Issue number3
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • antibiotics
  • partnerships
  • chlamydia infection
  • heterosexuality
  • infection
  • chlamydia
  • public health medicine

Cite this

Huffam, Sarah ; Chow, Eric Pui Fung ; Leeyaphan, Charussri ; Fairley, Christopher K ; Hocking, Jane ; Phillips, Samuel ; Tabrizi, Sepehr ; Bellhouse, Clare ; Bradshaw, Catriona S. ; Fehler, Glenda ; Garland, Suzanne ; Chen, Marcus Y. / Chlamydia Infection Between Men and Women : A Cross-Sectional Study of Heterosexual Partnerships. In: Open Forum Infectious Diseases. 2017 ; Vol. 4, No. 3.
@article{69114e5df42e49d289b617dba64c2074,
title = "Chlamydia Infection Between Men and Women: A Cross-Sectional Study of Heterosexual Partnerships",
abstract = "BackgroundStudies of sexual partnerships can further our understanding of the sexual transmission of chlamydia, which is important for informing public health interventions and clinical management. The aim of this study was to ascertain among heterosexual dyads the proportion concordantly infected with chlamydia and factors associated with infection between partners.MethodsThis study was conducted at the Melbourne Sexual Health Centre between January 2006 and March 2015. Heterosexual partners attending the clinic on the same day were identified prospectively. Dyads where 1 or both individuals were diagnosed with chlamydia by a test performed on the day of joint attendance or within the prior 30 days were included. Testing was by strand displacement assay. Men and women with genital symptoms underwent clinical examination.ResultsOf 233 females with chlamydia, 76{\%} (n = 178) of their male partners tested positive. Of the chlamydia-positive females with cervicitis, 91{\%} of males were chlamydia positive. Male infection was less likely if their partner had taken azithromycin or doxycycline within 30 days (7{\%} vs 25{\%}; P = .039). Of 235 males with chlamydia, 77{\%} (n = 178) of their female partners tested positive. No associations were found between male symptoms, signs, or recent antibiotic use and a positive chlamydia result in female partners. Sixty-one percent of the dyads were concordantly infected with chlamydia.ConclusionsThese results underscore the high likelihood of heterosexual partners of men and women with chlamydia being infected and the importance that partners are tested and managed appropriately for chlamydia.",
keywords = "antibiotics, partnerships, chlamydia infection, heterosexuality, infection, chlamydia, public health medicine",
author = "Sarah Huffam and Chow, {Eric Pui Fung} and Charussri Leeyaphan and Fairley, {Christopher K} and Jane Hocking and Samuel Phillips and Sepehr Tabrizi and Clare Bellhouse and Bradshaw, {Catriona S.} and Glenda Fehler and Suzanne Garland and Chen, {Marcus Y.}",
year = "2017",
month = "7",
day = "1",
doi = "10.1093/ofid/ofx160",
language = "English",
volume = "4",
journal = "Open Forum Infectious Diseases",
issn = "2328-8957",
number = "3",

}

Chlamydia Infection Between Men and Women : A Cross-Sectional Study of Heterosexual Partnerships. / Huffam, Sarah; Chow, Eric Pui Fung; Leeyaphan, Charussri; Fairley, Christopher K; Hocking, Jane; Phillips, Samuel; Tabrizi, Sepehr; Bellhouse, Clare; Bradshaw, Catriona S.; Fehler, Glenda; Garland, Suzanne; Chen, Marcus Y.

In: Open Forum Infectious Diseases, Vol. 4, No. 3, ofx160, 01.07.2017.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Chlamydia Infection Between Men and Women

T2 - A Cross-Sectional Study of Heterosexual Partnerships

AU - Huffam, Sarah

AU - Chow, Eric Pui Fung

AU - Leeyaphan, Charussri

AU - Fairley, Christopher K

AU - Hocking, Jane

AU - Phillips, Samuel

AU - Tabrizi, Sepehr

AU - Bellhouse, Clare

AU - Bradshaw, Catriona S.

AU - Fehler, Glenda

AU - Garland, Suzanne

AU - Chen, Marcus Y.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - BackgroundStudies of sexual partnerships can further our understanding of the sexual transmission of chlamydia, which is important for informing public health interventions and clinical management. The aim of this study was to ascertain among heterosexual dyads the proportion concordantly infected with chlamydia and factors associated with infection between partners.MethodsThis study was conducted at the Melbourne Sexual Health Centre between January 2006 and March 2015. Heterosexual partners attending the clinic on the same day were identified prospectively. Dyads where 1 or both individuals were diagnosed with chlamydia by a test performed on the day of joint attendance or within the prior 30 days were included. Testing was by strand displacement assay. Men and women with genital symptoms underwent clinical examination.ResultsOf 233 females with chlamydia, 76% (n = 178) of their male partners tested positive. Of the chlamydia-positive females with cervicitis, 91% of males were chlamydia positive. Male infection was less likely if their partner had taken azithromycin or doxycycline within 30 days (7% vs 25%; P = .039). Of 235 males with chlamydia, 77% (n = 178) of their female partners tested positive. No associations were found between male symptoms, signs, or recent antibiotic use and a positive chlamydia result in female partners. Sixty-one percent of the dyads were concordantly infected with chlamydia.ConclusionsThese results underscore the high likelihood of heterosexual partners of men and women with chlamydia being infected and the importance that partners are tested and managed appropriately for chlamydia.

AB - BackgroundStudies of sexual partnerships can further our understanding of the sexual transmission of chlamydia, which is important for informing public health interventions and clinical management. The aim of this study was to ascertain among heterosexual dyads the proportion concordantly infected with chlamydia and factors associated with infection between partners.MethodsThis study was conducted at the Melbourne Sexual Health Centre between January 2006 and March 2015. Heterosexual partners attending the clinic on the same day were identified prospectively. Dyads where 1 or both individuals were diagnosed with chlamydia by a test performed on the day of joint attendance or within the prior 30 days were included. Testing was by strand displacement assay. Men and women with genital symptoms underwent clinical examination.ResultsOf 233 females with chlamydia, 76% (n = 178) of their male partners tested positive. Of the chlamydia-positive females with cervicitis, 91% of males were chlamydia positive. Male infection was less likely if their partner had taken azithromycin or doxycycline within 30 days (7% vs 25%; P = .039). Of 235 males with chlamydia, 77% (n = 178) of their female partners tested positive. No associations were found between male symptoms, signs, or recent antibiotic use and a positive chlamydia result in female partners. Sixty-one percent of the dyads were concordantly infected with chlamydia.ConclusionsThese results underscore the high likelihood of heterosexual partners of men and women with chlamydia being infected and the importance that partners are tested and managed appropriately for chlamydia.

KW - antibiotics

KW - partnerships

KW - chlamydia infection

KW - heterosexuality

KW - infection

KW - chlamydia

KW - public health medicine

U2 - 10.1093/ofid/ofx160

DO - 10.1093/ofid/ofx160

M3 - Article

VL - 4

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

SN - 2328-8957

IS - 3

M1 - ofx160

ER -