TY - JOUR
T1 - Chitosan nanoparticles enhance the plasma exposure of (-) -epigallocatechin gallate in mice through an enhancement in intestinal stability
AU - Dube, Admire
AU - Nicolazzo, Joseph
AU - Larson, Ian
PY - 2011
Y1 - 2011
N2 - The green tea catechin (-)-epigallocatechin gallate (EGCG) has attracted significant research interest due to its beneficial therapeutic effects, which include anti-oxidant, neuro-protective and anti-cancer effects. However, the therapeutic potential of EGCG following oral consumption is limited by its poor absorption. To address this issue, EGCG has been encapsulated in chitosan-tripolyphosphate nanoparticles (CS NPs) and the oral absorption of EGCG evaluated in Swiss Outbred mice.
AB - The green tea catechin (-)-epigallocatechin gallate (EGCG) has attracted significant research interest due to its beneficial therapeutic effects, which include anti-oxidant, neuro-protective and anti-cancer effects. However, the therapeutic potential of EGCG following oral consumption is limited by its poor absorption. To address this issue, EGCG has been encapsulated in chitosan-tripolyphosphate nanoparticles (CS NPs) and the oral absorption of EGCG evaluated in Swiss Outbred mice.
UR - http://www.sciencedirect.com/science/article/pii/S0928098711003083
U2 - 10.1016/j.eps.2011.09.004
DO - 10.1016/j.eps.2011.09.004
M3 - Article
SN - 0928-0987
VL - 44
SP - 422
EP - 426
JO - European Journal of Pharmaceutical Sciences
JF - European Journal of Pharmaceutical Sciences
ER -
