Chitosan nanoparticles enhance the plasma exposure of (-) -epigallocatechin gallate in mice through an enhancement in intestinal stability

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Abstract

The green tea catechin (-)-epigallocatechin gallate (EGCG) has attracted significant research interest due to its beneficial therapeutic effects, which include anti-oxidant, neuro-protective and anti-cancer effects. However, the therapeutic potential of EGCG following oral consumption is limited by its poor absorption. To address this issue, EGCG has been encapsulated in chitosan-tripolyphosphate nanoparticles (CS NPs) and the oral absorption of EGCG evaluated in Swiss Outbred mice.
Original languageEnglish
Pages (from-to)422 - 426
Number of pages5
JournalEuropean Journal of Pharmaceutical Sciences
Volume44
DOIs
Publication statusPublished - 2011

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