Chitosan nanoparticles enhance the plasma exposure of (-) -epigallocatechin gallate in mice through an enhancement in intestinal stability

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Abstract

The green tea catechin (-)-epigallocatechin gallate (EGCG) has attracted significant research interest due to its beneficial therapeutic effects, which include anti-oxidant, neuro-protective and anti-cancer effects. However, the therapeutic potential of EGCG following oral consumption is limited by its poor absorption. To address this issue, EGCG has been encapsulated in chitosan-tripolyphosphate nanoparticles (CS NPs) and the oral absorption of EGCG evaluated in Swiss Outbred mice.
Original languageEnglish
Pages (from-to)422 - 426
Number of pages5
JournalEuropean Journal of Pharmaceutical Sciences
Volume44
DOIs
Publication statusPublished - 2011

Cite this

@article{5efa002a33534533803e998e589322d9,
title = "Chitosan nanoparticles enhance the plasma exposure of (-) -epigallocatechin gallate in mice through an enhancement in intestinal stability",
abstract = "The green tea catechin (-)-epigallocatechin gallate (EGCG) has attracted significant research interest due to its beneficial therapeutic effects, which include anti-oxidant, neuro-protective and anti-cancer effects. However, the therapeutic potential of EGCG following oral consumption is limited by its poor absorption. To address this issue, EGCG has been encapsulated in chitosan-tripolyphosphate nanoparticles (CS NPs) and the oral absorption of EGCG evaluated in Swiss Outbred mice.",
author = "Admire Dube and Joseph Nicolazzo and Ian Larson",
year = "2011",
doi = "10.1016/j.eps.2011.09.004",
language = "English",
volume = "44",
pages = "422 -- 426",
journal = "European Journal of Pharmaceutical Sciences",
issn = "0928-0987",
publisher = "Elsevier",

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AU - Dube, Admire

AU - Nicolazzo, Joseph

AU - Larson, Ian

PY - 2011

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N2 - The green tea catechin (-)-epigallocatechin gallate (EGCG) has attracted significant research interest due to its beneficial therapeutic effects, which include anti-oxidant, neuro-protective and anti-cancer effects. However, the therapeutic potential of EGCG following oral consumption is limited by its poor absorption. To address this issue, EGCG has been encapsulated in chitosan-tripolyphosphate nanoparticles (CS NPs) and the oral absorption of EGCG evaluated in Swiss Outbred mice.

AB - The green tea catechin (-)-epigallocatechin gallate (EGCG) has attracted significant research interest due to its beneficial therapeutic effects, which include anti-oxidant, neuro-protective and anti-cancer effects. However, the therapeutic potential of EGCG following oral consumption is limited by its poor absorption. To address this issue, EGCG has been encapsulated in chitosan-tripolyphosphate nanoparticles (CS NPs) and the oral absorption of EGCG evaluated in Swiss Outbred mice.

UR - http://www.sciencedirect.com/science/article/pii/S0928098711003083

U2 - 10.1016/j.eps.2011.09.004

DO - 10.1016/j.eps.2011.09.004

M3 - Article

VL - 44

SP - 422

EP - 426

JO - European Journal of Pharmaceutical Sciences

JF - European Journal of Pharmaceutical Sciences

SN - 0928-0987

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