Childhood wheeze phenotypes show less than expected growth in FEV1 across adolescence

Caroline J Lodge, Adrian J Lowe, Katrina J Allen, Sophie Zaloumis, Lyle C Gurrin, Melanie C Matheson, Christine Axelrad, Liam Welsh, Catherine Bennett, John L Hopper, Paul S Thomas, David J Hill, Clifford S Hosking, Cecilie Svanes, Michael John Abramson, Shyamali C Dharmage

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Abstract. Rationale: Better characterization of childhood wheeze phenotypes using newer statistical methods provides a basis for addressing the heterogeneity of childhood asthma. Outcomes of these phenotypes beyond childhood are unknown. Objectives: To determine if adolescent respiratory symptoms, lung function and changes in lung function over adolescence differ by childhood wheeze phenotypes defined through Latent Class Analysis. Methods: A prospective birth cohort (Melbourne Atopy Cohort Study) followed 620 high allergy-risk children, recording respiratory symptoms and spirometry at 12 and 18 years. Regression analyses identified relationships between wheeze phenotypes (Never/Infrequent ; Early Transient ; Early Persistent ; Intermediate Onset ; Late Onset ) and: lung function, change in lung function (12-18yrs), respiratory symptoms, and asthma. Baseline : Never/Infrequent wheeze. Measurements and Main Results: Deficits in expected growth of lung function, measured by change in pre-bronchodilator Forced Expiratory Volume over 1 second (FEV1) between 12 and 18 years were found for: Early Persistent (reduced 290mls; 95 CI 82,498); Intermediate Onset (reduced 210mls; 62,359); and Late Onset wheeze; (reduced 255mls; 69,442 ). Intermediate Onset wheezers had persistent FEV1 deficit post bronchodilator at 18 years (reduced 198mls; 46,350). Current asthma risk was increased for all phenotypes except Early Transient, which was also not associated with lung function deficits at 12 or 18 years. Conclusions: Persistent wheeze phenotypes in childhood were associated with reduced growth in pre-bronchodilator FEV1 over adolescence. Intermediate Onset wheezers showed irreversible airflow limitation by 18 years. Conversely, Early Transient wheeze was a benign condition with no sequelae for respiratory health by age 18.
Original languageEnglish
Pages (from-to)1351 - 1358
Number of pages8
JournalAmerican Journal of Respiratory and Critical Care Medicine
Issue number11
Publication statusPublished - 2014

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Lodge, C. J., Lowe, A. J., Allen, K. J., Zaloumis, S., Gurrin, L. C., Matheson, M. C., Axelrad, C., Welsh, L., Bennett, C., Hopper, J. L., Thomas, P. S., Hill, D. J., Hosking, C. S., Svanes, C., Abramson, M. J., & Dharmage, S. C. (2014). Childhood wheeze phenotypes show less than expected growth in FEV1 across adolescence. American Journal of Respiratory and Critical Care Medicine, 189(11), 1351 - 1358.