Childhood pneumococcal diseases and serotypes: Can vaccines protect?

Kam Lun Hon, Margaret Ip, Kenneth Lee, Edmund Anthony Nelson, Ka Ho Eric Shea, Yiu Sang Tony Yuen, Ting Fan Leung

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)


Objectives To describe pneumococcal diseases in pediatric intensive care unit (PICU) and non-PICU patients. Methods The clinical, serotypes, and antibacterial sensitivity patterns of all children admitted to the pediatric wards (including PICU) of a university-affiliated teaching hospital from 2007 through 2009 with pneumococcal isolates were reviewed. Results Twelve cases of pneumococcal disease in children from 2007 through 2009 were reported. Five patients were admitted to PICU and 7 were general pediatric admissions. Four patients (2 PICU and 2 general pediatric) had received full or partial 7-valent pneumococcal vaccinations. All four patients recovered following systemic antibiotic treatment without sequelae. The serotypes of all PICU and some general pediatric cases were available and included 3, 6B, 19A and 19F. All isolates were sensitive to vancomycin. 50% were intermediate resistant/resistant to penicillin and 17% resistant to cefotaxime. PICU cases required longer total hospital stay (23 days vs 5 days, p=0.013). Three patients were ventilated and one received inotropic support. There was no death in this series. Conclusions Pneumococcal disease may develop despite prior vaccination. The expanded coverage of newer polyvalent pneumococcal vaccines might have prevented some, but not all, of these admissions.

Original languageEnglish
Pages (from-to)1387-1391
Number of pages5
JournalIndian Journal of Pediatrics
Issue number12
Publication statusPublished - Dec 2010
Externally publishedYes


  • Antibiotic resistance
  • Invasive S pneumoniae
  • Septicemia

Cite this