Childhood eczema and rhinitis predict atopic but not nonatopic adult asthma: A prospective cohort study over 4 decades

Pamela Martin; Melanie C Matheson; Lyle Gurrin; John Burgess; Nicholas Osborne; Adrian Lowe; Stephen Morrison; Desiree Meszaros; Graham G Giles; Michael John Abramson; E Haydn Walters; Katrina Allen; Shyamali C Dharmage

doi:10.1016/j.jaci.2011.02.041

Childhood eczema and rhinitis predict atopic but not nonatopic adult asthma: A prospective cohort study over 4 decades

Pamela Martin, Melanie C Matheson, Lyle Gurrin, John Burgess, Nicholas Osborne, Adrian Lowe, Stephen Morrison, Desiree Meszaros, Graham G Giles, Michael John Abramson, E Haydn Walters, Katrina Allen, Shyamali C Dharmage

Epidemiology and Preventive Medicine Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

90 Citations (Scopus)

Abstract

Background The evidence on whether the atopic march observed in childhood (ie, the progression from eczema to allergic rhinitis and asthma) extends to adulthood is sparse, and there is no evidence on whether the progression leads to a specific phenotype of asthma. Objective We sought to assess whether childhood eczema and rhinitis are risk factors for specific phenotypes of adult asthma. Methods Participants of the Tasmanian Longitudinal Health Study recruited in 1968 (age range, 6.0-7.0 years) were followed up at age 44 years. The risk of current atopic or nonatopic asthma in middle age characterized by sensitization to aeroallergens given childhood eczema, rhinitis, or both was calculated by using multinomial logistic regression.

Original language	English
Pages (from-to)	1473 - 1479
Number of pages	7
Journal	The Journal of Allergy and Clinical Immunology
Volume	127
Issue number	6
DOIs	https://doi.org/10.1016/j.jaci.2011.02.041
Publication status	Published - 2011

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10.1016/j.jaci.2011.02.041

Cite this

Martin, P., Matheson, M. C., Gurrin, L., Burgess, J., Osborne, N., Lowe, A., Morrison, S., Meszaros, D., Giles, G. G., Abramson, M. J., Walters, E. H., Allen, K., & Dharmage, S. C. (2011). Childhood eczema and rhinitis predict atopic but not nonatopic adult asthma: A prospective cohort study over 4 decades. The Journal of Allergy and Clinical Immunology, 127(6), 1473 - 1479. https://doi.org/10.1016/j.jaci.2011.02.041

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title = "Childhood eczema and rhinitis predict atopic but not nonatopic adult asthma: A prospective cohort study over 4 decades",

abstract = "Background The evidence on whether the atopic march observed in childhood (ie, the progression from eczema to allergic rhinitis and asthma) extends to adulthood is sparse, and there is no evidence on whether the progression leads to a specific phenotype of asthma. Objective We sought to assess whether childhood eczema and rhinitis are risk factors for specific phenotypes of adult asthma. Methods Participants of the Tasmanian Longitudinal Health Study recruited in 1968 (age range, 6.0-7.0 years) were followed up at age 44 years. The risk of current atopic or nonatopic asthma in middle age characterized by sensitization to aeroallergens given childhood eczema, rhinitis, or both was calculated by using multinomial logistic regression.",

author = "Pamela Martin and Matheson, {Melanie C} and Lyle Gurrin and John Burgess and Nicholas Osborne and Adrian Lowe and Stephen Morrison and Desiree Meszaros and Giles, {Graham G} and Abramson, {Michael John} and Walters, {E Haydn} and Katrina Allen and Dharmage, {Shyamali C}",

year = "2011",

doi = "10.1016/j.jaci.2011.02.041",

language = "English",

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Martin, P, Matheson, MC, Gurrin, L, Burgess, J, Osborne, N, Lowe, A, Morrison, S, Meszaros, D, Giles, GG, Abramson, MJ, Walters, EH, Allen, K & Dharmage, SC 2011, 'Childhood eczema and rhinitis predict atopic but not nonatopic adult asthma: A prospective cohort study over 4 decades', The Journal of Allergy and Clinical Immunology, vol. 127, no. 6, pp. 1473 - 1479. https://doi.org/10.1016/j.jaci.2011.02.041

TY - JOUR

T1 - Childhood eczema and rhinitis predict atopic but not nonatopic adult asthma: A prospective cohort study over 4 decades

AU - Martin, Pamela

AU - Matheson, Melanie C

AU - Gurrin, Lyle

AU - Burgess, John

AU - Osborne, Nicholas

AU - Lowe, Adrian

AU - Morrison, Stephen

AU - Meszaros, Desiree

AU - Giles, Graham G

AU - Abramson, Michael John

AU - Walters, E Haydn

AU - Allen, Katrina

AU - Dharmage, Shyamali C

PY - 2011

Y1 - 2011

N2 - Background The evidence on whether the atopic march observed in childhood (ie, the progression from eczema to allergic rhinitis and asthma) extends to adulthood is sparse, and there is no evidence on whether the progression leads to a specific phenotype of asthma. Objective We sought to assess whether childhood eczema and rhinitis are risk factors for specific phenotypes of adult asthma. Methods Participants of the Tasmanian Longitudinal Health Study recruited in 1968 (age range, 6.0-7.0 years) were followed up at age 44 years. The risk of current atopic or nonatopic asthma in middle age characterized by sensitization to aeroallergens given childhood eczema, rhinitis, or both was calculated by using multinomial logistic regression.

AB - Background The evidence on whether the atopic march observed in childhood (ie, the progression from eczema to allergic rhinitis and asthma) extends to adulthood is sparse, and there is no evidence on whether the progression leads to a specific phenotype of asthma. Objective We sought to assess whether childhood eczema and rhinitis are risk factors for specific phenotypes of adult asthma. Methods Participants of the Tasmanian Longitudinal Health Study recruited in 1968 (age range, 6.0-7.0 years) were followed up at age 44 years. The risk of current atopic or nonatopic asthma in middle age characterized by sensitization to aeroallergens given childhood eczema, rhinitis, or both was calculated by using multinomial logistic regression.

U2 - 10.1016/j.jaci.2011.02.041

DO - 10.1016/j.jaci.2011.02.041

M3 - Article

SN - 0091-6749

VL - 127

SP - 1473

EP - 1479

JO - The Journal of Allergy and Clinical Immunology

JF - The Journal of Allergy and Clinical Immunology

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