Childhood eczema and rhinitis predict atopic but not nonatopic adult asthma: A prospective cohort study over 4 decades

Pamela Martin, Melanie C Matheson, Lyle Gurrin, John Burgess, Nicholas Osborne, Adrian Lowe, Stephen Morrison, Desiree Meszaros, Graham G Giles, Michael John Abramson, E Haydn Walters, Katrina Allen, Shyamali C Dharmage

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Background The evidence on whether the atopic march observed in childhood (ie, the progression from eczema to allergic rhinitis and asthma) extends to adulthood is sparse, and there is no evidence on whether the progression leads to a specific phenotype of asthma. Objective We sought to assess whether childhood eczema and rhinitis are risk factors for specific phenotypes of adult asthma. Methods Participants of the Tasmanian Longitudinal Health Study recruited in 1968 (age range, 6.0-7.0 years) were followed up at age 44 years. The risk of current atopic or nonatopic asthma in middle age characterized by sensitization to aeroallergens given childhood eczema, rhinitis, or both was calculated by using multinomial logistic regression.
Original languageEnglish
Pages (from-to)1473 - 1479
Number of pages7
JournalThe Journal of Allergy and Clinical Immunology
Issue number6 (Art. No: e1)
Publication statusPublished - 2011

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