Childhood body mass index and adult mammographic density measures that predict breast cancer risk

John L. Hopper, Tuong L. Nguyen, Jennifer Stone, Kelly Aujard, Melanie C. Matheson, Michael J. Abramson, John A. Burgess, E. Haydn Walters, Gillian S. Dite, Minh Bui, Christopher Evans, Enes Makalic, Daniel F. Schmidt, Gail Ward, Mark A. Jenkins, Graham G. Giles, Shyamali C. Dharmage, Carmel Apicella

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12 Citations (Scopus)

Abstract

The aim of the present study is to determine if body mass index (BMI) during childhood is associated with the breast cancer risk factor ‘adult mammographic density adjusted for age and BMI’. In 1968, the Tasmanian Longitudinal Health Study studied every Tasmanian school child born in 1961. We obtained measured heights and weights from annual school medical records across ages 7–15 years and imputed missing values. Between 2009 and 2012, we administered to 490 women a questionnaire that asked current height and weight and digitised at least one mammogram per woman. Absolute and percent mammographic densities were measured using the computer-assisted method CUMULUS. We used linear regression and adjusted for age at interview and log current BMI. The mammographic density measures were negatively associated: with log BMI at each age from 7 to 15 years (all p 

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalBreast Cancer Research and Treatment
Volume156
Issue number1
DOIs
Publication statusPublished - 1 Feb 2016

Keywords

  • Adolescence
  • Body mass index
  • Breast cancer
  • Childhood growth
  • Mammographic density
  • Prospective study

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