Chicken osteoclasts do not possess calcitonin receptors

G. C. Nicholson, J. M. Moseley, P. M. Sexton, T. J. Martin

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Abstract

Osteoclasts freshly isolated from embryonic chicks have been examined for calcitonin receptors using radio‐iodine‐labeled salmon calcitonin. Calcitonin binding to chick osteoclasts could not be shown by either autoradiography or biochemical binding studies. Furthermore, calcitonin did not stimulate cyclic AMP production. By contrast, rat osteoclasts have abundant calcitonin receptors, and a sensitive cyclic AMP response to calcitonin has been shown previously. It is concluded that chick osteoclasts do not possess calcitonin receptors, a finding which could explain the lack of calcitonin responsiveness observed in other avian osteoclast culture systems.

Original languageEnglish
Pages (from-to)53-59
Number of pages7
JournalJournal of Bone and Mineral Research
Volume2
Issue number1
DOIs
Publication statusPublished - 1 Jan 1987
Externally publishedYes

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