TY - JOUR
T1 - Chemokines and chemokine receptors: New actors in neuroendocrine regulations
AU - Rostene, William
AU - Guyon, Alice
AU - Kular, Lara
AU - Godefroy, David
AU - Barbieri, Federica
AU - Bajetto, Adriana
AU - Banisadr, Ghazal
AU - Callewaere, Celine
AU - Conductier, Gregory
AU - Rovere, Carole
AU - Melik-Parsadaniantz, Stephane
AU - Florio, Tullio
PY - 2011
Y1 - 2011
N2 - Chemokines are small secreted proteins that chemoattract and activate immune and non-immune cells. Their role in the immune system is well-known, and it has recently been suggested that they may also play a role in the central nervous system (CNS). Indeed, they do not only act as immunoinflammatory mediators in the brain but they also act as potential modulators in neurotransmission. Although we are only beginning to be aware of the implication of chemokines in neuroendocrine functions, this review aims at summarizing what is known in that booming field of research. First we describe the expression of chemokines and their receptors in the CNS with a focus on the hypothalamo-pituitary system. Secondly, we present what is known on some chemokines in the regulation of neuroendocrine functions such as cell migration, stress, thermoregulation, drinking and feeding as well as anterior pituitary functions. We suggest that chemokines provide a fine modulatory tuning system of neuroendocrine regulations
AB - Chemokines are small secreted proteins that chemoattract and activate immune and non-immune cells. Their role in the immune system is well-known, and it has recently been suggested that they may also play a role in the central nervous system (CNS). Indeed, they do not only act as immunoinflammatory mediators in the brain but they also act as potential modulators in neurotransmission. Although we are only beginning to be aware of the implication of chemokines in neuroendocrine functions, this review aims at summarizing what is known in that booming field of research. First we describe the expression of chemokines and their receptors in the CNS with a focus on the hypothalamo-pituitary system. Secondly, we present what is known on some chemokines in the regulation of neuroendocrine functions such as cell migration, stress, thermoregulation, drinking and feeding as well as anterior pituitary functions. We suggest that chemokines provide a fine modulatory tuning system of neuroendocrine regulations
U2 - 10.1016/j.yfrne.2010.07.001
DO - 10.1016/j.yfrne.2010.07.001
M3 - Article
VL - 32
SP - 10
EP - 24
JO - Frontiers in Neuroendocrinology
JF - Frontiers in Neuroendocrinology
SN - 0091-3022
IS - 1
ER -