Chemokines and chemokine receptors in T-cell priming and Th1/Th2- mediated responses

Federica Sallusto, Antonio Lanzavecchia, Charles R. MacKay

Research output: Contribution to journalReview ArticleResearchpeer-review

498 Citations (Scopus)


T-cell priming occurs in the lymphoid tissue via T cell-dendritic cell interaction. Conversely, delayed-type hypersensitivity or allergic reactions can occur in any tissue, following interaction of T helper 1 (Th1) or Th2 cells with effector leukocytes. Here, Federica Sallusto and colleagues review the role played by chemokines and chemokine receptors in positioning T cells for the immune response.

Original languageEnglish
Pages (from-to)568-574
Number of pages7
JournalImmunology Today
Issue number12
Publication statusPublished - 1 Dec 1998
Externally publishedYes

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