Chemokine expression in simian immunodeficiency virus-induced AIDS encephalitis

Vito G. Sasseville, Martha M. Smith, Charles R. Mackay, Douglas R. Pauley, Keith G. Mansfield, Douglas J. Ringler, Andrew A. Lackner

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Abstract

The pathogenesis of neurological dysfunction associated with human immunodeficiency (HIV)-1 infection is uncertain. However, the presence of macrophage infiltrates in the central nervous system is a key feature of HIV encephalitis and is correlated with HIV-associated dementia. Moreover, it has been demonstrated that HIV-infected monocyte/macrophages can produce toxic substances that may play a critical role in the development of HIV-associated dementia. However, the exact mechanisms responsible for HIV infection and leukocyte recruitment to the central nervous system remain speculative. Similar to HIV-infected patients, simian immunodeficiency virus (SIV)- infected macaque monkeys develop immunosuppression and acquired immune deficiency syndrome (AIDS)-related inflammatory disorders, including AIDS encephalitis. In this study, we demonstrate that encephalitic brain from SIV- infected animals has elevated immunohistochemical expression of the C-C chemokines, macrophage inflammatory protein-1α and -β, RANTES, and monocyte chemotactic protein-3, and the C-X-C chemokine interferon-inducible protein- 10. These findings suggest that one or all of these chemokines could be involved in leukocyte recruitment to the brain in SIV-infected macaque monkeys.

Original languageEnglish
Pages (from-to)1459-1467
Number of pages9
JournalAmerican Journal of Pathology
Volume149
Issue number5
Publication statusPublished - 1 Nov 1996
Externally publishedYes

Cite this

Sasseville, V. G., Smith, M. M., Mackay, C. R., Pauley, D. R., Mansfield, K. G., Ringler, D. J., & Lackner, A. A. (1996). Chemokine expression in simian immunodeficiency virus-induced AIDS encephalitis. American Journal of Pathology, 149(5), 1459-1467.