Chemoattractants and their receptors in homeostasis and inflammation

Federica Sallusto, Charles R. MacKay

Research output: Contribution to journalReview ArticleResearchpeer-review

90 Citations (Scopus)

Abstract

The study of leukocyte migration continues to provide new insights into the regulation of lymphocyte priming in secondary lymphoid organs and effector responses in inflamed tissues. Chemoattractant receptors have always been viewed as facilitators of cell movement into a tissue. This whole concept must now be revised with the discovery of sphingosine 1 phosphate receptors, which control cell exit from lymphoid tissues. The chemoattractants that regulate lymphoid tissue homing are usually different to those that regulate leukocyte recruitment to inflamed tissues. There is evidence, however, of inflammatory pathways of leukocyte recruitment in lymph nodes and, conversely of constitutive pathways in peripheral tissues. Finally, antagonists (or agonists) of chemoattractant receptors and their signalling pathways represent the most attractive strategy for the treatment of a wide range of inflammatory diseases, including allergy.

Original languageEnglish
Pages (from-to)724-731
Number of pages8
JournalCurrent Opinion in Immunology
Volume16
Issue number6
DOIs
Publication statusPublished - 1 Dec 2004
Externally publishedYes

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