TY - JOUR
T1 - Chemoattractants and their receptors in homeostasis and inflammation
AU - Sallusto, Federica
AU - MacKay, Charles R.
PY - 2004/12/1
Y1 - 2004/12/1
N2 - The study of leukocyte migration continues to provide new insights into the regulation of lymphocyte priming in secondary lymphoid organs and effector responses in inflamed tissues. Chemoattractant receptors have always been viewed as facilitators of cell movement into a tissue. This whole concept must now be revised with the discovery of sphingosine 1 phosphate receptors, which control cell exit from lymphoid tissues. The chemoattractants that regulate lymphoid tissue homing are usually different to those that regulate leukocyte recruitment to inflamed tissues. There is evidence, however, of inflammatory pathways of leukocyte recruitment in lymph nodes and, conversely of constitutive pathways in peripheral tissues. Finally, antagonists (or agonists) of chemoattractant receptors and their signalling pathways represent the most attractive strategy for the treatment of a wide range of inflammatory diseases, including allergy.
AB - The study of leukocyte migration continues to provide new insights into the regulation of lymphocyte priming in secondary lymphoid organs and effector responses in inflamed tissues. Chemoattractant receptors have always been viewed as facilitators of cell movement into a tissue. This whole concept must now be revised with the discovery of sphingosine 1 phosphate receptors, which control cell exit from lymphoid tissues. The chemoattractants that regulate lymphoid tissue homing are usually different to those that regulate leukocyte recruitment to inflamed tissues. There is evidence, however, of inflammatory pathways of leukocyte recruitment in lymph nodes and, conversely of constitutive pathways in peripheral tissues. Finally, antagonists (or agonists) of chemoattractant receptors and their signalling pathways represent the most attractive strategy for the treatment of a wide range of inflammatory diseases, including allergy.
UR - http://www.scopus.com/inward/record.url?scp=7044233625&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2004.09.012
DO - 10.1016/j.coi.2004.09.012
M3 - Review Article
C2 - 15511664
AN - SCOPUS:7044233625
SN - 0952-7915
VL - 16
SP - 724
EP - 731
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 6
ER -