TY - JOUR
T1 - Chemo-enzymatic synthesis and RAFT polymerization of 6-O-methacryloyl mannose
T2 - A suitable glycopolymer for binding to the tetrameric lectin concanavalin A?
AU - Granville, Anthony M.
AU - Quémener, Damien
AU - Davis, Thomas P.
AU - Barner-Kowollik, Christopher
AU - Stenzel, Martina H.
PY - 2007/10/22
Y1 - 2007/10/22
N2 - The chemo-enzymatic synthesis of 6-O-methacryloyl mannose (MaM) glycomonomer was successfully performed for the first time. Subsequent aqueous RAFT polymerization of the monomer yielded well-defined, linear poly(6-O-methacryloyl mannose) (PMaM) glycopolymers without the need for protecting and deprotecting group chemistry. As well as investigating the RAFT polymerization kinetics of this monomer using various initial monomer to chain transfer agent concentration ratios, the protein binding ability of the generated glycopolymer was tested using concanavalin A, a known mannose-residue binding lectin.
AB - The chemo-enzymatic synthesis of 6-O-methacryloyl mannose (MaM) glycomonomer was successfully performed for the first time. Subsequent aqueous RAFT polymerization of the monomer yielded well-defined, linear poly(6-O-methacryloyl mannose) (PMaM) glycopolymers without the need for protecting and deprotecting group chemistry. As well as investigating the RAFT polymerization kinetics of this monomer using various initial monomer to chain transfer agent concentration ratios, the protein binding ability of the generated glycopolymer was tested using concanavalin A, a known mannose-residue binding lectin.
KW - Glycopolymer
KW - Protein binding
KW - RAFT polymerization
KW - Reversible addition-fragmentation chain transfer polymerization
UR - http://www.scopus.com/inward/record.url?scp=35348891438&partnerID=8YFLogxK
U2 - 10.1002/masy.200750909
DO - 10.1002/masy.200750909
M3 - Article
AN - SCOPUS:35348891438
VL - 255
SP - 81
EP - 89
JO - Macromolecular Symposia
JF - Macromolecular Symposia
SN - 1022-1360
ER -