TY - JOUR
T1 - Chemistry, biosynthesis and pharmacology of sarsasapogenin
T2 - A potential natural steroid molecule for new drug design, development and therapy
AU - Mustafa, Nur Hanisah
AU - Sekar, Mahendran
AU - Fuloria, Shivkanya
AU - Begum, M. Yasmin
AU - Gan, Siew Hua
AU - Rani, Nur Najihah Izzati Mat
AU - Ravi, Subban
AU - Chidambaram, Kumarappan
AU - Subramaniyan, Vetriselvan
AU - Sathasivam, Kathiresan V.
AU - Jeyabalan, Srikanth
AU - Uthirapathy, Subasini
AU - Ponnusankar, Sivasankaran
AU - Lum, Pei Teng
AU - Bhalla, Vijay
AU - Fuloria, Neeraj Kumar
N1 - Funding Information:
This study was funded by the Deanship of Scientific Research (RGP: 1/275/1442), King Khalid University, Abha, Saudi Arabia.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/3/2
Y1 - 2022/3/2
N2 - Sarsasapogenin is a natural steroidal sapogenin molecule obtained mainly from Anemar-rhena asphodeloides Bunge. Among the various phytosteroids present, sarsasapogenin has emerged as a promising molecule due to the fact of its diverse pharmacological activities. In this review, the chemistry, biosynthesis and pharmacological potentials of sarsasapogenin are summarised. Between 1996 and the present, the relevant literature regarding sarsasapogenin was obtained from scientific databases including PubMed, ScienceDirect, Scopus, and Google Scholar. Overall, sarsasapogenin is a potent molecule with anti-inflammatory, anticancer, antidiabetic, anti-osteoclastogenic and neu-roprotective activities. It is also a potential molecule in the treatment for precocious puberty. This review also discusses the metabolism, pharmacokinetics and possible structural modifications as well as obstacles and opportunities for sarsasapogenin to become a drug molecule in the near future. More comprehensive preclinical studies, clinical trials, drug delivery, formulations of effective doses in pharmacokinetics studies, evaluation of adverse effects and potential synergistic effects with other drugs need to be thoroughly investigated to make sarsasapogenin a potential molecule for future drug development.
AB - Sarsasapogenin is a natural steroidal sapogenin molecule obtained mainly from Anemar-rhena asphodeloides Bunge. Among the various phytosteroids present, sarsasapogenin has emerged as a promising molecule due to the fact of its diverse pharmacological activities. In this review, the chemistry, biosynthesis and pharmacological potentials of sarsasapogenin are summarised. Between 1996 and the present, the relevant literature regarding sarsasapogenin was obtained from scientific databases including PubMed, ScienceDirect, Scopus, and Google Scholar. Overall, sarsasapogenin is a potent molecule with anti-inflammatory, anticancer, antidiabetic, anti-osteoclastogenic and neu-roprotective activities. It is also a potential molecule in the treatment for precocious puberty. This review also discusses the metabolism, pharmacokinetics and possible structural modifications as well as obstacles and opportunities for sarsasapogenin to become a drug molecule in the near future. More comprehensive preclinical studies, clinical trials, drug delivery, formulations of effective doses in pharmacokinetics studies, evaluation of adverse effects and potential synergistic effects with other drugs need to be thoroughly investigated to make sarsasapogenin a potential molecule for future drug development.
KW - biosynthesis
KW - drug development
KW - pharmacology
KW - phytochemistry
KW - sarsasapogenin
KW - steroid
UR - http://www.scopus.com/inward/record.url?scp=85127026271&partnerID=8YFLogxK
U2 - 10.3390/molecules27062032
DO - 10.3390/molecules27062032
M3 - Review Article
C2 - 35335393
AN - SCOPUS:85127026271
VL - 27
JO - Molecules
JF - Molecules
SN - 1420-3049
IS - 6
M1 - 2032
ER -