Chemistry, biosynthesis and pharmacology of sarsasapogenin: A potential natural steroid molecule for new drug design, development and therapy

Nur Hanisah Mustafa, Mahendran Sekar, Shivkanya Fuloria, M. Yasmin Begum, Siew Hua Gan, Nur Najihah Izzati Mat Rani, Subban Ravi, Kumarappan Chidambaram, Vetriselvan Subramaniyan, Kathiresan V. Sathasivam, Srikanth Jeyabalan, Subasini Uthirapathy, Sivasankaran Ponnusankar, Pei Teng Lum, Vijay Bhalla, Neeraj Kumar Fuloria

Research output: Contribution to journalReview ArticleResearchpeer-review

8 Citations (Scopus)

Abstract

Sarsasapogenin is a natural steroidal sapogenin molecule obtained mainly from Anemar-rhena asphodeloides Bunge. Among the various phytosteroids present, sarsasapogenin has emerged as a promising molecule due to the fact of its diverse pharmacological activities. In this review, the chemistry, biosynthesis and pharmacological potentials of sarsasapogenin are summarised. Between 1996 and the present, the relevant literature regarding sarsasapogenin was obtained from scientific databases including PubMed, ScienceDirect, Scopus, and Google Scholar. Overall, sarsasapogenin is a potent molecule with anti-inflammatory, anticancer, antidiabetic, anti-osteoclastogenic and neu-roprotective activities. It is also a potential molecule in the treatment for precocious puberty. This review also discusses the metabolism, pharmacokinetics and possible structural modifications as well as obstacles and opportunities for sarsasapogenin to become a drug molecule in the near future. More comprehensive preclinical studies, clinical trials, drug delivery, formulations of effective doses in pharmacokinetics studies, evaluation of adverse effects and potential synergistic effects with other drugs need to be thoroughly investigated to make sarsasapogenin a potential molecule for future drug development.

Original languageEnglish
Article number2032
Number of pages26
JournalMolecules
Volume27
Issue number6
DOIs
Publication statusPublished - 2 Mar 2022

Keywords

  • biosynthesis
  • drug development
  • pharmacology
  • phytochemistry
  • sarsasapogenin
  • steroid

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