A method for ecstasy volatiles a??signaturea?? analysis based on two-dimensional gas chromatography separation and time-of-flight mass spectrometry detection (GC ?? GC-TOFMS) is presented. Organic impurity volatiles were extracted by head space solid phase microextraction (HS-SPME). The final column phase choice of the four different column combinations tested was a low-polarity 5 phenyl polysilphenylene-siloxane coupled with a polyethylene glycol phase, which best displayed the complex impurity profile. Second dimension (2D) retention time reproducibility was found to be about 1 RSD, and area reproducibility of SPME sampling was just over 5 RSD for compounds with S/N ratio of about 100.
Mitrevski, B., Veleska, B., Engel, E., Wynne, P., Song, S-M., & Marriott, P. (2011). Chemical signature of ecstasy volatiles by comprehensive two-dimensional gas chromatography. Forensic Science International, 209(1-3), 11 - 20. https://doi.org/10.1016/j.forsciint.2010.11.008