Chemical shift properties of hyperpolarized 129Xe in brain tissue

Kazuhiro Nakamura; Atsushi Wakai; Jeff Kershaw; Yasushi Kondoh; David K Wright; Iwao Kanno

doi:10.11239/jsmbe2002.42.378

Chemical shift properties of hyperpolarized ¹²⁹Xe in brain tissue

Kazuhiro Nakamura, Atsushi Wakai, Jeff Kershaw, Yasushi Kondoh, David K Wright, Iwao Kanno

Research output: Contribution to journal › Article › Research › peer-review

Abstract

After the inhalation of hyperpolarized 129Xe gas, in vivo spectra from the rat head revealed a dominant peak around 195ppm (Peak A) and another easily resolvable peak near 189ppm (Peak B). We have already confirmed that peak A and peak B originate from brain and non-brain tissue, respectively. In order to confirm that the properties of 129Xe in non-brain tissue are different from those in brain tissue, a comparison is made of the washout times of 129Xe from the brain and non-brain tissues using a strict two-pulse measurement protocol from 12 rats. The washout time of peak B (25.4±10.4sec) was consistently longer than that of peak A (14.7±1.0sec) . Blood flow through scalp tissue and muscle is approximately one-tenth of that in the brain. Hence, it is reasonable to assume that the washout time of the non-brain peak is longer.

Original language	English
Pages (from-to)	378-383
Number of pages	6
Journal	Transactions of Japanese Society for Medical and Biological Engineering
Volume	42
Issue number	4
DOIs	https://doi.org/10.11239/jsmbe2002.42.378
Publication status	Published - 1 Oct 2004
Externally published	Yes

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10.11239/jsmbe2002.42.378

Cite this

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title = "Chemical shift properties of hyperpolarized 129Xe in brain tissue",

abstract = "After the inhalation of hyperpolarized 129Xe gas, in vivo spectra from the rat head revealed a dominant peak around 195ppm (Peak A) and another easily resolvable peak near 189ppm (Peak B). We have already confirmed that peak A and peak B originate from brain and non-brain tissue, respectively. In order to confirm that the properties of 129Xe in non-brain tissue are different from those in brain tissue, a comparison is made of the washout times of 129Xe from the brain and non-brain tissues using a strict two-pulse measurement protocol from 12 rats. The washout time of peak B (25.4±10.4sec) was consistently longer than that of peak A (14.7±1.0sec) . Blood flow through scalp tissue and muscle is approximately one-tenth of that in the brain. Hence, it is reasonable to assume that the washout time of the non-brain peak is longer.",

author = "Kazuhiro Nakamura and Atsushi Wakai and Jeff Kershaw and Yasushi Kondoh and Wright, {David K} and Iwao Kanno",

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T1 - Chemical shift properties of hyperpolarized 129Xe in brain tissue

AU - Nakamura, Kazuhiro

AU - Wakai, Atsushi

AU - Kershaw, Jeff

AU - Kondoh, Yasushi

AU - Wright, David K

AU - Kanno, Iwao

PY - 2004/10/1

Y1 - 2004/10/1

N2 - After the inhalation of hyperpolarized 129Xe gas, in vivo spectra from the rat head revealed a dominant peak around 195ppm (Peak A) and another easily resolvable peak near 189ppm (Peak B). We have already confirmed that peak A and peak B originate from brain and non-brain tissue, respectively. In order to confirm that the properties of 129Xe in non-brain tissue are different from those in brain tissue, a comparison is made of the washout times of 129Xe from the brain and non-brain tissues using a strict two-pulse measurement protocol from 12 rats. The washout time of peak B (25.4±10.4sec) was consistently longer than that of peak A (14.7±1.0sec) . Blood flow through scalp tissue and muscle is approximately one-tenth of that in the brain. Hence, it is reasonable to assume that the washout time of the non-brain peak is longer.

AB - After the inhalation of hyperpolarized 129Xe gas, in vivo spectra from the rat head revealed a dominant peak around 195ppm (Peak A) and another easily resolvable peak near 189ppm (Peak B). We have already confirmed that peak A and peak B originate from brain and non-brain tissue, respectively. In order to confirm that the properties of 129Xe in non-brain tissue are different from those in brain tissue, a comparison is made of the washout times of 129Xe from the brain and non-brain tissues using a strict two-pulse measurement protocol from 12 rats. The washout time of peak B (25.4±10.4sec) was consistently longer than that of peak A (14.7±1.0sec) . Blood flow through scalp tissue and muscle is approximately one-tenth of that in the brain. Hence, it is reasonable to assume that the washout time of the non-brain peak is longer.

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DO - 10.11239/jsmbe2002.42.378

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