Chemical constituents and evaluation of cytotoxic activities of Curcuma zedoaria (Christm.) Roscoe oils from Malaysia and Indonesia

Devi Rosmy Syamsir; Yasodha Sivasothy; Hazrina Hazni; Sri Nurestri Abdul Malek; Noor Hasima Nagoor; Halijah Ibrahim; Khalijah Awang

doi:10.1080/0972060X.2017.1362997

Chemical constituents and evaluation of cytotoxic activities of Curcuma zedoaria (Christm.) Roscoe oils from Malaysia and Indonesia

Devi Rosmy Syamsir
, Yasodha Sivasothy
, Hazrina Hazni
, Sri Nurestri Abdul Malek
, Noor Hasima Nagoor
, Halijah Ibrahim
, Khalijah Awang

Research output: Contribution to journal › Article › Research › peer-review

13 Citations (Scopus)

Abstract

The essential oils obtained by hydrodistillation of the rhizomes of Curcuma zedoaria (Christm.) Roscoe collected from Malaysia and Indonesia were analyzed by capillary GC and GC-MS. Both the oils were principally sesquiterpenic in nature and were characterized by zerumbone (17.14% and 12.07%, respectively). Camphor (17.56% and 19.69%, respectively) was also abundant in both oils. The cytotoxic effects of both the oils on human breast (MCF-7 and MDA-MB 231), lung (A549 and SK-LU-1) and cervical (HeLa S3 and SiHa) cancer cell lines were examined using the MTT assay. The Malaysian C. zedoaria rhizome oil was found to be cytotoxic against the MCF-7, SK-LU-1, HeLa S3 and SiHa cell lines, with IC₅₀ values being less than 10 μg/mL. Our findings support the use of the Malaysian C. zedoaria rhizome oil as a potential chemopreventive agent towards a wide spectrum of cancer in particular cervical cancer.

Original language	English
Pages (from-to)	972-982
Number of pages	11
Journal	Journal of Essential Oil-Bearing Plants
Volume	20
Issue number	4
DOIs	https://doi.org/10.1080/0972060X.2017.1362997
Publication status	Published - 4 Jul 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Curcuma zedoaria (Christm.) Roscoe
cytotoxic effects
essential oil
MTT assay

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10.1080/0972060X.2017.1362997

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title = "Chemical constituents and evaluation of cytotoxic activities of Curcuma zedoaria (Christm.) Roscoe oils from Malaysia and Indonesia",

abstract = "The essential oils obtained by hydrodistillation of the rhizomes of Curcuma zedoaria (Christm.) Roscoe collected from Malaysia and Indonesia were analyzed by capillary GC and GC-MS. Both the oils were principally sesquiterpenic in nature and were characterized by zerumbone (17.14\% and 12.07\%, respectively). Camphor (17.56\% and 19.69\%, respectively) was also abundant in both oils. The cytotoxic effects of both the oils on human breast (MCF-7 and MDA-MB 231), lung (A549 and SK-LU-1) and cervical (HeLa S3 and SiHa) cancer cell lines were examined using the MTT assay. The Malaysian C. zedoaria rhizome oil was found to be cytotoxic against the MCF-7, SK-LU-1, HeLa S3 and SiHa cell lines, with IC50 values being less than 10 μg/mL. Our findings support the use of the Malaysian C. zedoaria rhizome oil as a potential chemopreventive agent towards a wide spectrum of cancer in particular cervical cancer.",

keywords = "Curcuma zedoaria (Christm.) Roscoe, cytotoxic effects, essential oil, MTT assay",

author = "Syamsir, \{Devi Rosmy\} and Yasodha Sivasothy and Hazrina Hazni and \{Abdul Malek\}, \{Sri Nurestri\} and Nagoor, \{Noor Hasima\} and Halijah Ibrahim and Khalijah Awang",

note = "Funding Information: This project was funded by University of Malaya Postgraduate Research Grant (PPP) (PV050/ 2012A) and University of Malaya Research Grant (UMRG) (RP001/2012A/B). Publisher Copyright: {\textcopyright} 2017 Har Krishan Bhalla \& Sons. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

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doi = "10.1080/0972060X.2017.1362997",

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T1 - Chemical constituents and evaluation of cytotoxic activities of Curcuma zedoaria (Christm.) Roscoe oils from Malaysia and Indonesia

AU - Syamsir, Devi Rosmy

AU - Sivasothy, Yasodha

AU - Hazni, Hazrina

AU - Abdul Malek, Sri Nurestri

AU - Nagoor, Noor Hasima

AU - Ibrahim, Halijah

AU - Awang, Khalijah

N1 - Funding Information: This project was funded by University of Malaya Postgraduate Research Grant (PPP) (PV050/ 2012A) and University of Malaya Research Grant (UMRG) (RP001/2012A/B). Publisher Copyright: © 2017 Har Krishan Bhalla & Sons. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2017/7/4

Y1 - 2017/7/4

N2 - The essential oils obtained by hydrodistillation of the rhizomes of Curcuma zedoaria (Christm.) Roscoe collected from Malaysia and Indonesia were analyzed by capillary GC and GC-MS. Both the oils were principally sesquiterpenic in nature and were characterized by zerumbone (17.14% and 12.07%, respectively). Camphor (17.56% and 19.69%, respectively) was also abundant in both oils. The cytotoxic effects of both the oils on human breast (MCF-7 and MDA-MB 231), lung (A549 and SK-LU-1) and cervical (HeLa S3 and SiHa) cancer cell lines were examined using the MTT assay. The Malaysian C. zedoaria rhizome oil was found to be cytotoxic against the MCF-7, SK-LU-1, HeLa S3 and SiHa cell lines, with IC50 values being less than 10 μg/mL. Our findings support the use of the Malaysian C. zedoaria rhizome oil as a potential chemopreventive agent towards a wide spectrum of cancer in particular cervical cancer.

AB - The essential oils obtained by hydrodistillation of the rhizomes of Curcuma zedoaria (Christm.) Roscoe collected from Malaysia and Indonesia were analyzed by capillary GC and GC-MS. Both the oils were principally sesquiterpenic in nature and were characterized by zerumbone (17.14% and 12.07%, respectively). Camphor (17.56% and 19.69%, respectively) was also abundant in both oils. The cytotoxic effects of both the oils on human breast (MCF-7 and MDA-MB 231), lung (A549 and SK-LU-1) and cervical (HeLa S3 and SiHa) cancer cell lines were examined using the MTT assay. The Malaysian C. zedoaria rhizome oil was found to be cytotoxic against the MCF-7, SK-LU-1, HeLa S3 and SiHa cell lines, with IC50 values being less than 10 μg/mL. Our findings support the use of the Malaysian C. zedoaria rhizome oil as a potential chemopreventive agent towards a wide spectrum of cancer in particular cervical cancer.

KW - Curcuma zedoaria (Christm.) Roscoe

KW - cytotoxic effects

KW - essential oil

KW - MTT assay

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Chemical constituents and evaluation of cytotoxic activities of Curcuma zedoaria (Christm.) Roscoe oils from Malaysia and Indonesia

Abstract

UN SDGs

Keywords

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