Chelation therapy for methylmercury(II) poisoning. Synthesis and determination of solubility properties of MeHg(II) complexes of thiol and dithiol anti

Alan P. Arnold, Allan J. Canty, Patrick W. Moors, Glen B. Deacon

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Abstract

Methylmercury(II) complexes of the most widely studied antidotes for mercury poisoning have been prepared, and both the water solubility and 1 -octanol/water partition coefficients determined for these complexes and the L-cysteine complex. New complexes of N-acetyl-D,L-penicillamine, 2-mercaptosuccinic acid, meso-dimercaptosuccinic acid, and Unithiol have been synthesized and characterized, and are found to have the formulations MeHgSCMe2CH(NHCOMe)CO2H, MeHgSCH(CO2H)CH2CO2H, MeHgSCH(CO2H)CH(CO2H)SHgMe, and Na[MeHgSCH2CH(SHgMe)CH2SO3], respectively Trends in octanol/water meso-dimercaptosuccinic acid.

Original languageEnglish
Pages (from-to)319-327
Number of pages9
JournalJournal of Inorganic Biochemistry
Volume19
Issue number4
DOIs
Publication statusPublished - 1983

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