TY - JOUR
T1 - Chelation therapy for methylmercury(II) poisoning. Synthesis and determination of solubility properties of MeHg(II) complexes of thiol and dithiol anti
AU - Arnold, Alan P.
AU - Canty, Allan J.
AU - Moors, Patrick W.
AU - Deacon, Glen B.
PY - 1983
Y1 - 1983
N2 - Methylmercury(II) complexes of the most widely studied antidotes for mercury poisoning have been prepared, and both the water solubility and 1 -octanol/water partition coefficients determined for these complexes and the L-cysteine complex. New complexes of N-acetyl-D,L-penicillamine, 2-mercaptosuccinic acid, meso-dimercaptosuccinic acid, and Unithiol have been synthesized and characterized, and are found to have the formulations MeHgSCMe2CH(NHCOMe)CO2H, MeHgSCH(CO2H)CH2CO2H, MeHgSCH(CO2H)CH(CO2H)SHgMe, and Na[MeHgSCH2CH(SHgMe)CH2SO3], respectively Trends in octanol/water meso-dimercaptosuccinic acid.
AB - Methylmercury(II) complexes of the most widely studied antidotes for mercury poisoning have been prepared, and both the water solubility and 1 -octanol/water partition coefficients determined for these complexes and the L-cysteine complex. New complexes of N-acetyl-D,L-penicillamine, 2-mercaptosuccinic acid, meso-dimercaptosuccinic acid, and Unithiol have been synthesized and characterized, and are found to have the formulations MeHgSCMe2CH(NHCOMe)CO2H, MeHgSCH(CO2H)CH2CO2H, MeHgSCH(CO2H)CH(CO2H)SHgMe, and Na[MeHgSCH2CH(SHgMe)CH2SO3], respectively Trends in octanol/water meso-dimercaptosuccinic acid.
UR - http://www.scopus.com/inward/record.url?scp=0021012723&partnerID=8YFLogxK
U2 - 10.1016/0162-0134(83)80005-1
DO - 10.1016/0162-0134(83)80005-1
M3 - Article
C2 - 6655472
AN - SCOPUS:0021012723
VL - 19
SP - 319
EP - 327
JO - Journal of Inorganic Biochemistry
JF - Journal of Inorganic Biochemistry
SN - 0162-0134
IS - 4
ER -