Characterizing cerebral oxygen metabolism employing oxygen-17 MRI/MRS at high fields

Ali Gordji-Nejad, Klaus Möllenhoff, Ana Maria Oros-Peusquens, Deepu R. Pillai, Nadim Jon Shah

Research output: Contribution to journalReview ArticleOtherpeer-review

15 Citations (Scopus)

Abstract

This article provides a comprehensive overview of oxygen (17O) magnetic resonance spectroscopy and imaging, including the advantages and challenges offered by the different methods developed thus far. The physiological role and relevance of oxygen, and its participation in aerobic metabolism, are addressed to emphasize the importance of the investigations and the efforts related to these developments. Furthermore, a number of methods employed in the determination of the cerebral metabolic rate of oxygen in neural cells will be presented, focusing primarily on methodologies enabling absolute quantification.

Original languageEnglish
Pages (from-to)81-93
Number of pages13
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Volume27
Issue number1
DOIs
Publication statusPublished - Feb 2014
Externally publishedYes

Keywords

  • Metabolism
  • Methods
  • MRI
  • Oxygen
  • Spectroscopy

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