Characterizing cerebral oxygen metabolism employing oxygen-17 MRI/MRS at high fields

Ali Gordji-Nejad; Klaus Möllenhoff; Ana Maria Oros-Peusquens; Deepu R. Pillai; Nadim Jon Shah

doi:10.1007/s10334-013-0413-4

Characterizing cerebral oxygen metabolism employing oxygen-17 MRI/MRS at high fields

Ali Gordji-Nejad, Klaus Möllenhoff, Ana Maria Oros-Peusquens, Deepu R. Pillai, Nadim Jon Shah

Research output: Contribution to journal › Review Article › Other › peer-review

21 Citations (Scopus)

Abstract

This article provides a comprehensive overview of oxygen (¹⁷O) magnetic resonance spectroscopy and imaging, including the advantages and challenges offered by the different methods developed thus far. The physiological role and relevance of oxygen, and its participation in aerobic metabolism, are addressed to emphasize the importance of the investigations and the efforts related to these developments. Furthermore, a number of methods employed in the determination of the cerebral metabolic rate of oxygen in neural cells will be presented, focusing primarily on methodologies enabling absolute quantification.

Original language	English
Pages (from-to)	81-93
Number of pages	13
Journal	Magnetic Resonance Materials in Physics, Biology and Medicine
Volume	27
Issue number	1
DOIs	https://doi.org/10.1007/s10334-013-0413-4
Publication status	Published - Feb 2014
Externally published	Yes

Keywords

Metabolism
Methods
MRI
Oxygen
Spectroscopy

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10.1007/s10334-013-0413-4

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AU - Pillai, Deepu R.

AU - Shah, Nadim Jon

PY - 2014/2

Y1 - 2014/2

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AB - This article provides a comprehensive overview of oxygen (17O) magnetic resonance spectroscopy and imaging, including the advantages and challenges offered by the different methods developed thus far. The physiological role and relevance of oxygen, and its participation in aerobic metabolism, are addressed to emphasize the importance of the investigations and the efforts related to these developments. Furthermore, a number of methods employed in the determination of the cerebral metabolic rate of oxygen in neural cells will be presented, focusing primarily on methodologies enabling absolute quantification.

KW - Metabolism

KW - Methods

KW - MRI

KW - Oxygen

KW - Spectroscopy

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M3 - Review Article

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JO - Magnetic Resonance Materials in Physics, Biology and Medicine

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ER -

Characterizing cerebral oxygen metabolism employing oxygen-17 MRI/MRS at high fields

Abstract

Keywords

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