Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277

Lin Zhou; Andre Alker; Armin Ruf; Xiaofang Wang; Francis Chi Keung Chiu; Julia Morizzi; Susan Ann Charman; William Neil Charman; Christian Scheurer; Sergio Wittlin; Yuxiang Dong; Daniel Hunziker; Jonathan Vennerstrom

Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277

Lin Zhou
, Andre Alker
, Armin Ruf
, Xiaofang Wang
, Francis Chi Keung Chiu
, Julia Morizzi
, Susan Ann Charman
, William Neil Charman
, Christian Scheurer
, Sergio Wittlin
, Yuxiang Dong
, Daniel Hunziker
, Jonathan Vennerstrom

Research output: Contribution to journal › Article › Research › peer-review

Abstract

The antimalarial synthetic ozonide OZ277 (RBx11160) was hydroxylated by human liver microsomes at the distal bridge-head carbon atoms of the spiroadamantane substructure to form two carbinol metabolites devoid of antimalarial activity.

Original language	English
Pages (from-to)	1555 - 1558
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	18
Issue number	5
Publication status	Published - 2008

Cite this

@article{91321ac6fdff4d49a2e36f8c0d45b900,

title = "Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277",

abstract = "The antimalarial synthetic ozonide OZ277 (RBx11160) was hydroxylated by human liver microsomes at the distal bridge-head carbon atoms of the spiroadamantane substructure to form two carbinol metabolites devoid of antimalarial activity.",

author = "Lin Zhou and Andre Alker and Armin Ruf and Xiaofang Wang and Chiu, \{Francis Chi Keung\} and Julia Morizzi and Charman, \{Susan Ann\} and Charman, \{William Neil\} and Christian Scheurer and Sergio Wittlin and Yuxiang Dong and Daniel Hunziker and Jonathan Vennerstrom",

year = "2008",

language = "English",

volume = "18",

pages = "1555 -- 1558",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier",

number = "5",

}

TY - JOUR

T1 - Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277

AU - Zhou, Lin

AU - Alker, Andre

AU - Ruf, Armin

AU - Wang, Xiaofang

AU - Chiu, Francis Chi Keung

AU - Morizzi, Julia

AU - Charman, Susan Ann

AU - Charman, William Neil

AU - Scheurer, Christian

AU - Wittlin, Sergio

AU - Dong, Yuxiang

AU - Hunziker, Daniel

AU - Vennerstrom, Jonathan

PY - 2008

Y1 - 2008

N2 - The antimalarial synthetic ozonide OZ277 (RBx11160) was hydroxylated by human liver microsomes at the distal bridge-head carbon atoms of the spiroadamantane substructure to form two carbinol metabolites devoid of antimalarial activity.

AB - The antimalarial synthetic ozonide OZ277 (RBx11160) was hydroxylated by human liver microsomes at the distal bridge-head carbon atoms of the spiroadamantane substructure to form two carbinol metabolites devoid of antimalarial activity.

M3 - Article

SN - 0960-894X

VL - 18

SP - 1555

EP - 1558

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 5

ER -