Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277

Lin Zhou, Andre Alker, Armin Ruf, Xiaofang Wang, Francis Chi Keung Chiu, Julia Morizzi, Susan Ann Charman, William Neil Charman, Christian Scheurer, Sergio Wittlin, Yuxiang Dong, Daniel Hunziker, Jonathan Vennerstrom

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32 Citations (Scopus)

Abstract

The antimalarial synthetic ozonide OZ277 (RBx11160) was hydroxylated by human liver microsomes at the distal bridge-head carbon atoms of the spiroadamantane substructure to form two carbinol metabolites devoid of antimalarial activity.
Original languageEnglish
Pages (from-to)1555 - 1558
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number5
Publication statusPublished - 2008

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