Characterization of the acute pulse transit time response to obstructive apneas and hypopneas in preschool children with sleep-disordered breathing

Lauren Nisbet, Stephanie Yiallourou, Gillian Michelle Nixon, Sarah Nichole Biggs, Margot J Davey, John A Trinder, Lisa Mary Walter, Rosemary Sylvia Claire Horne

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)


Surges in heart rate (HR) and blood pressure (BP) at apnea termination contribute to the hypertension seen in obstructive sleep apnea (OSA). Because childhood OSA prevalence peaks in the preschool years, we aimed to characterize the cardiovascular response to obstructive events in preschool-aged children. METHODS: Clinically referred children aged 3-5years were grouped by obstructive apnea-hypopnea index (OAHI) into the following: primary snoring (PS) (OAHI1event/h [n=21]), mild OSA (OAHI>1-5 [n=32]), and moderate to severe (MS) OSA (OAHI>5 [n=28]). Beat-to-beat pulse transit time (PTT), an inverse continuous indicator of BP changes, and HR were averaged during the two halves (early and late) and during the peak after (post) each obstructive event and were expressed as percentage change from late- to post-event. RESULTS: We analyzed 422 events consisting of 55 apneas and 367 hypopneas. A significant post-event increase in HR and fall in PTT occurred in all severity groups (P
Original languageEnglish
Pages (from-to)1123 - 1131
Number of pages9
JournalSleep Medicine
Issue number11
Publication statusPublished - 2013

Cite this