Characterization of recombinant tetanus toxin derivatives suitable for vaccine development

D. Figueiredo; C. Turcotte; G. Frankel; Y. Li; O. Dolly; G. Wilkin; D. Marriott; N. Fairweather; G. Dougan

Characterization of recombinant tetanus toxin derivatives suitable for vaccine development

D. Figueiredo, C. Turcotte, G. Frankel, Y. Li, O. Dolly, G. Wilkin, D. Marriott, N. Fairweather, G. Dougan

Research output: Contribution to journal › Comment / Debate › Other › peer-review

Abstract

Recombinant derivatives of tetanus toxin (TeTx) were isolated and used to immunize mice. Recombinant TeTx light chain, a derivative of fragment C that had lost the ability to bind neurons, and a recombinant TeTx holotoxoid that could protect mice against TeTx challenge were identified.

Original language	English
Pages (from-to)	3218-3221
Number of pages	4
Journal	Infection and Immunity
Volume	63
Issue number	8
Publication status	Published - 1 Jan 1995
Externally published	Yes

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@article{474e851b9bf3438b9da7c6668e1f7088,

title = "Characterization of recombinant tetanus toxin derivatives suitable for vaccine development",

abstract = "Recombinant derivatives of tetanus toxin (TeTx) were isolated and used to immunize mice. Recombinant TeTx light chain, a derivative of fragment C that had lost the ability to bind neurons, and a recombinant TeTx holotoxoid that could protect mice against TeTx challenge were identified.",

author = "D. Figueiredo and C. Turcotte and G. Frankel and Y. Li and O. Dolly and G. Wilkin and D. Marriott and N. Fairweather and G. Dougan",

year = "1995",

month = jan,

day = "1",

language = "English",

volume = "63",

pages = "3218--3221",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "8",

}

TY - JOUR

T1 - Characterization of recombinant tetanus toxin derivatives suitable for vaccine development

AU - Figueiredo, D.

AU - Turcotte, C.

AU - Frankel, G.

AU - Li, Y.

AU - Dolly, O.

AU - Wilkin, G.

AU - Marriott, D.

AU - Fairweather, N.

AU - Dougan, G.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Recombinant derivatives of tetanus toxin (TeTx) were isolated and used to immunize mice. Recombinant TeTx light chain, a derivative of fragment C that had lost the ability to bind neurons, and a recombinant TeTx holotoxoid that could protect mice against TeTx challenge were identified.

AB - Recombinant derivatives of tetanus toxin (TeTx) were isolated and used to immunize mice. Recombinant TeTx light chain, a derivative of fragment C that had lost the ability to bind neurons, and a recombinant TeTx holotoxoid that could protect mice against TeTx challenge were identified.

UR - http://www.scopus.com/inward/record.url?scp=0029168005&partnerID=8YFLogxK

M3 - Comment / Debate

C2 - 7622252

AN - SCOPUS:0029168005

SN - 0019-9567

VL - 63

SP - 3218

EP - 3221

JO - Infection and Immunity

JF - Infection and Immunity

IS - 8

ER -

Characterization of recombinant tetanus toxin derivatives suitable for vaccine development

Abstract

UN SDGs

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