Characterization of recombinant tetanus toxin derivatives suitable for vaccine development

D. Figueiredo, C. Turcotte, G. Frankel, Y. Li, O. Dolly, G. Wilkin, D. Marriott, N. Fairweather, G. Dougan

Research output: Contribution to journalComment / DebateOtherpeer-review

33 Citations (Scopus)

Abstract

Recombinant derivatives of tetanus toxin (TeTx) were isolated and used to immunize mice. Recombinant TeTx light chain, a derivative of fragment C that had lost the ability to bind neurons, and a recombinant TeTx holotoxoid that could protect mice against TeTx challenge were identified.

Original languageEnglish
Pages (from-to)3218-3221
Number of pages4
JournalInfection and Immunity
Volume63
Issue number8
Publication statusPublished - 1 Jan 1995
Externally publishedYes

Cite this

Figueiredo, D., Turcotte, C., Frankel, G., Li, Y., Dolly, O., Wilkin, G., Marriott, D., Fairweather, N., & Dougan, G. (1995). Characterization of recombinant tetanus toxin derivatives suitable for vaccine development. Infection and Immunity, 63(8), 3218-3221.