TY - JOUR
T1 - Characterization of mocarhagin, a cobra. Venom metalloproteinase from Naja mocambique mocambique, and related proteins from other elapidae venoms
AU - Ward, Christopher M.
AU - Vinogradov, Dimitri V.
AU - Andrews, Robert K.
AU - Berndt, Michael C.
PY - 1996/1/1
Y1 - 1996/1/1
N2 - Mocarhagin, a cobra venom metalloproteinase from Naja mocambique mocambique, has previously been shown to cleave selectively two mucin-like substrates on platelets and neutrophils within anionic amino acid sequences containing sulfated tyrosines. We now show that purified mocarhagin has haemagglutinin activity, and a similar profile for inhibition of mocarhagin-dependent haemagglutination and proteolysis suggests that the lectin-like domain may account for its substrate specificity. In addition, immunologically and functionally related proteins were detected in other Elapidae venoms.
AB - Mocarhagin, a cobra venom metalloproteinase from Naja mocambique mocambique, has previously been shown to cleave selectively two mucin-like substrates on platelets and neutrophils within anionic amino acid sequences containing sulfated tyrosines. We now show that purified mocarhagin has haemagglutinin activity, and a similar profile for inhibition of mocarhagin-dependent haemagglutination and proteolysis suggests that the lectin-like domain may account for its substrate specificity. In addition, immunologically and functionally related proteins were detected in other Elapidae venoms.
UR - http://www.scopus.com/inward/record.url?scp=0010229714&partnerID=8YFLogxK
U2 - 10.1016/0041-0101(96)00115-8
DO - 10.1016/0041-0101(96)00115-8
M3 - Article
C2 - 8931262
AN - SCOPUS:0010229714
SN - 0041-0101
VL - 34
SP - 1203
EP - 1206
JO - Toxicon
JF - Toxicon
IS - 10
ER -