Characterization of mocarhagin, a cobra. Venom metalloproteinase from Naja mocambique mocambique, and related proteins from other elapidae venoms

Christopher M. Ward, Dimitri V. Vinogradov, Robert K. Andrews, Michael C. Berndt

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Abstract

Mocarhagin, a cobra venom metalloproteinase from Naja mocambique mocambique, has previously been shown to cleave selectively two mucin-like substrates on platelets and neutrophils within anionic amino acid sequences containing sulfated tyrosines. We now show that purified mocarhagin has haemagglutinin activity, and a similar profile for inhibition of mocarhagin-dependent haemagglutination and proteolysis suggests that the lectin-like domain may account for its substrate specificity. In addition, immunologically and functionally related proteins were detected in other Elapidae venoms.

Original languageEnglish
Pages (from-to)1203-1206
Number of pages4
JournalToxicon
Volume34
Issue number10
DOIs
Publication statusPublished - 1 Jan 1996
Externally publishedYes

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