TY - JOUR
T1 - Characterization of migration parameters on peripheral and central nervous system T cells following treatment of experimental allergic encephalomyelitis with CRYAB
AU - Oyebamiji, Adeola I
AU - Finlay, Trisha M
AU - Hough, Rachael M
AU - Hoghooghi, Vahid
AU - Lim, Erin-Mai F
AU - Wong, Connie Hoi Yee
AU - Ousman, Shalina S
PY - 2013
Y1 - 2013
N2 - CRYAB, a small heat shock protein, was previously shown to decrease neuroinflammation in experimental allergic encephalomyelitis (EAE). We investigated whether the expression of cell adhesion molecules and chemokine receptors on peripheral and spinal cord T cells, that could possibly affect their migration to the central nervous system, was altered following EAE CRYAB treatment. Less LFA-1+ lymphocytes and lower levels of iTAC, MCP-5 and MIG were observed in spinal cords of CRYAB-injected EAE animals. In addition, fewer blood T cells expressed CCR6, CXCR4 and CCR7 and in vivo-derived CRYAB EAE CD4+ lymphocytes were less migratory towards a MIP-3alpha gradient in vitro.
AB - CRYAB, a small heat shock protein, was previously shown to decrease neuroinflammation in experimental allergic encephalomyelitis (EAE). We investigated whether the expression of cell adhesion molecules and chemokine receptors on peripheral and spinal cord T cells, that could possibly affect their migration to the central nervous system, was altered following EAE CRYAB treatment. Less LFA-1+ lymphocytes and lower levels of iTAC, MCP-5 and MIG were observed in spinal cords of CRYAB-injected EAE animals. In addition, fewer blood T cells expressed CCR6, CXCR4 and CCR7 and in vivo-derived CRYAB EAE CD4+ lymphocytes were less migratory towards a MIP-3alpha gradient in vitro.
UR - http://www.ncbi.nlm.nih.gov/pubmed/23602713
U2 - 10.1016/j.jneuroim.2013.03.007
DO - 10.1016/j.jneuroim.2013.03.007
M3 - Article
SN - 0165-5728
VL - 259
SP - 66
EP - 74
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -