Characterization of interferons produced by peripheral blood mononuclear cells from healthy subjects in response to Corynebacterium parvum or poly I: poly C

P. J. Hertzog; B. F. Cheetham; J. L. Sexton; A. W. Linnane

Characterization of interferons produced by peripheral blood mononuclear cells from healthy subjects in response to Corynebacterium parvum or poly I: poly C

P. J. Hertzog, B. F. Cheetham, J. L. Sexton, A. W. Linnane

Research output: Contribution to journal › Article › Research › peer-review

Abstract

The biological significance of acid labile interferon α is presently unknown. We examined the putative production of acid labile interferon in vitro from human peripheral blood mononuclear cells induced with Corynebacterium parvum or poly I: poly C. Both agents induced up to 1200 IU/ml interferon, and the interferon was 80 to 90% acid labile. The interferons were typed by antibody neutralization of their antiviral activity. Contrary to previous reports, C. parvum induced predominantly interferon γ, which is normally acid labile, whereas poly I: poly C induced an acid labile interferon α activity with characteristics similar to those of acid labile interferon α reported in serum in certain human diseases.

Original language	English
Pages (from-to)	1427-1436
Number of pages	10
Journal	Biochemistry International
Volume	19
Issue number	6
Publication status	Published - 1 Dec 1989

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title = "Characterization of interferons produced by peripheral blood mononuclear cells from healthy subjects in response to Corynebacterium parvum or poly I: poly C",

abstract = "The biological significance of acid labile interferon α is presently unknown. We examined the putative production of acid labile interferon in vitro from human peripheral blood mononuclear cells induced with Corynebacterium parvum or poly I: poly C. Both agents induced up to 1200 IU/ml interferon, and the interferon was 80 to 90% acid labile. The interferons were typed by antibody neutralization of their antiviral activity. Contrary to previous reports, C. parvum induced predominantly interferon γ, which is normally acid labile, whereas poly I: poly C induced an acid labile interferon α activity with characteristics similar to those of acid labile interferon α reported in serum in certain human diseases.",

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AU - Hertzog, P. J.

AU - Cheetham, B. F.

AU - Sexton, J. L.

AU - Linnane, A. W.

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AB - The biological significance of acid labile interferon α is presently unknown. We examined the putative production of acid labile interferon in vitro from human peripheral blood mononuclear cells induced with Corynebacterium parvum or poly I: poly C. Both agents induced up to 1200 IU/ml interferon, and the interferon was 80 to 90% acid labile. The interferons were typed by antibody neutralization of their antiviral activity. Contrary to previous reports, C. parvum induced predominantly interferon γ, which is normally acid labile, whereas poly I: poly C induced an acid labile interferon α activity with characteristics similar to those of acid labile interferon α reported in serum in certain human diseases.

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JF - Biochemistry and Molecular Biology International

SN - 1039-9712

IS - 6

ER -

Characterization of interferons produced by peripheral blood mononuclear cells from healthy subjects in response to Corynebacterium parvum or poly I: poly C

Abstract

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