Characterization of interferons produced by peripheral blood mononuclear cells from healthy subjects in response to Corynebacterium parvum or poly I: poly C

P. J. Hertzog, B. F. Cheetham, J. L. Sexton, A. W. Linnane

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The biological significance of acid labile interferon α is presently unknown. We examined the putative production of acid labile interferon in vitro from human peripheral blood mononuclear cells induced with Corynebacterium parvum or poly I: poly C. Both agents induced up to 1200 IU/ml interferon, and the interferon was 80 to 90% acid labile. The interferons were typed by antibody neutralization of their antiviral activity. Contrary to previous reports, C. parvum induced predominantly interferon γ, which is normally acid labile, whereas poly I: poly C induced an acid labile interferon α activity with characteristics similar to those of acid labile interferon α reported in serum in certain human diseases.

Original languageEnglish
Pages (from-to)1427-1436
Number of pages10
JournalBiochemistry International
Issue number6
Publication statusPublished - 1 Dec 1989

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