Characterization of central α-adrenoceptors using 3H-clonidine and its derivatives

B. Jarrott, W. J. Louis, R. J. Summers

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6 Citations (Scopus)

Abstract

α-Adrenoceptors in brain can be studied readily by radioligand binding techniques. This provides valuable information not only on the distribution of receptors in brain regions, but also on the regulation of receptors. The usefulness of this technique is dependent in part on a radioligand with high specificity for the receptor under study. Our studies have shown that 3H-clonidine does not bind exclusively to α2-adrenoceptor subtypes, but also interacts with α1-adrenoceptors. In contrast, 3H-guanfacine labels a high affinity α2 subtype with good selectivity, but 3H-lofexidine probably labels with both α2- and α1-adrenoceptor binding sites.

Original languageEnglish
Pages (from-to)339-340
Number of pages2
JournalChest
Volume83
Issue numberSuppl. 2
Publication statusPublished - 1 Jan 1983

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