Characterization of avian influenza viruses A (H5N1) from wild birds, Hong Kong, 2004-2008

Gavin J D Smith; Dhanasekaran Vijaykrishna; Trevor M. Ellis; Kitman C. Dyrting; Y. H Connie Leung; Justin Bahl; Chun W. Wong; Huang Kai; Mary K W Chow; Lian Duan; Allen S L Chan; Li Juan Zhang; Honglin Chen; Geraldine S M Luk; J. S Malik Peiris; Yi Guan

doi:10.3201/eid1503.081190

Characterization of avian influenza viruses A (H5N1) from wild birds, Hong Kong, 2004-2008

Gavin J D Smith, Dhanasekaran Vijaykrishna, Trevor M. Ellis, Kitman C. Dyrting, Y. H Connie Leung, Justin Bahl, Chun W. Wong, Huang Kai, Mary K W Chow, Lian Duan, Allen S L Chan, Li Juan Zhang, Honglin Chen, Geraldine S M Luk, J. S Malik Peiris, Yi Guan

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Abstract

From January 2004 through June 2008, surveillance of dead wild birds in Hong Kong, People's Republic of China, periodically detected highly pathogenic avian influenza (HPAI) viruses (H5N1) in individual birds from different species. During this period, no viruses of subtype H5N1 were detected in poultry on farms and in markets in Hong Kong despite intensive surveillance. Thus, these findings in wild birds demonstrate the potential for wild birds to disseminate HPAI viruses (H5N1) to areas otherwise free from the viruses. Genetic and antigenic characterization of 47 HPAI (H5N1) viruses isolated from dead wild birds in Hong Kong showed that these isolates belonged to 2 antigenically distinct virus groups: clades 2.3.4 and 2.3.2. Although research has shown that clade 2.3.4 viruses are established in poultry in Asia, the emergence of clade 2.3.2 viruses in nonpasserine birds from Hong Kong, Japan, and Russia raises the possibility that this virus lineage may have become established in wild birds.

Original language	English
Pages (from-to)	402-407
Number of pages	6
Journal	Emerging Infectious Diseases
Volume	15
Issue number	3
DOIs	https://doi.org/10.3201/eid1503.081190
Publication status	Published - Mar 2009
Externally published	Yes

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Smith, G. J. D., Vijaykrishna, D., Ellis, T. M., Dyrting, K. C., Leung, Y. H. C., Bahl, J., Wong, C. W., Kai, H., Chow, M. K. W., Duan, L., Chan, A. S. L., Zhang, L. J., Chen, H., Luk, G. S. M., Peiris, J. S. M., & Guan, Y. (2009). Characterization of avian influenza viruses A (H5N1) from wild birds, Hong Kong, 2004-2008. Emerging Infectious Diseases, 15(3), 402-407. https://doi.org/10.3201/eid1503.081190

@article{5b182cad39144440b1ca34a481a80fcf,

title = "Characterization of avian influenza viruses A (H5N1) from wild birds, Hong Kong, 2004-2008",

abstract = "From January 2004 through June 2008, surveillance of dead wild birds in Hong Kong, People's Republic of China, periodically detected highly pathogenic avian influenza (HPAI) viruses (H5N1) in individual birds from different species. During this period, no viruses of subtype H5N1 were detected in poultry on farms and in markets in Hong Kong despite intensive surveillance. Thus, these findings in wild birds demonstrate the potential for wild birds to disseminate HPAI viruses (H5N1) to areas otherwise free from the viruses. Genetic and antigenic characterization of 47 HPAI (H5N1) viruses isolated from dead wild birds in Hong Kong showed that these isolates belonged to 2 antigenically distinct virus groups: clades 2.3.4 and 2.3.2. Although research has shown that clade 2.3.4 viruses are established in poultry in Asia, the emergence of clade 2.3.2 viruses in nonpasserine birds from Hong Kong, Japan, and Russia raises the possibility that this virus lineage may have become established in wild birds.",

author = "Smith, {Gavin J D} and Dhanasekaran Vijaykrishna and Ellis, {Trevor M.} and Dyrting, {Kitman C.} and Leung, {Y. H Connie} and Justin Bahl and Wong, {Chun W.} and Huang Kai and Chow, {Mary K W} and Lian Duan and Chan, {Allen S L} and Zhang, {Li Juan} and Honglin Chen and Luk, {Geraldine S M} and Peiris, {J. S Malik} and Yi Guan",

year = "2009",

month = mar,

doi = "10.3201/eid1503.081190",

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Smith, GJD, Vijaykrishna, D, Ellis, TM, Dyrting, KC, Leung, YHC, Bahl, J, Wong, CW, Kai, H, Chow, MKW, Duan, L, Chan, ASL, Zhang, LJ, Chen, H, Luk, GSM, Peiris, JSM & Guan, Y 2009, 'Characterization of avian influenza viruses A (H5N1) from wild birds, Hong Kong, 2004-2008', Emerging Infectious Diseases, vol. 15, no. 3, pp. 402-407. https://doi.org/10.3201/eid1503.081190

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AU - Vijaykrishna, Dhanasekaran

AU - Ellis, Trevor M.

AU - Dyrting, Kitman C.

AU - Leung, Y. H Connie

AU - Bahl, Justin

AU - Wong, Chun W.

AU - Kai, Huang

AU - Chow, Mary K W

AU - Duan, Lian

AU - Chan, Allen S L

AU - Zhang, Li Juan

AU - Chen, Honglin

AU - Luk, Geraldine S M

AU - Peiris, J. S Malik

AU - Guan, Yi

PY - 2009/3

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N2 - From January 2004 through June 2008, surveillance of dead wild birds in Hong Kong, People's Republic of China, periodically detected highly pathogenic avian influenza (HPAI) viruses (H5N1) in individual birds from different species. During this period, no viruses of subtype H5N1 were detected in poultry on farms and in markets in Hong Kong despite intensive surveillance. Thus, these findings in wild birds demonstrate the potential for wild birds to disseminate HPAI viruses (H5N1) to areas otherwise free from the viruses. Genetic and antigenic characterization of 47 HPAI (H5N1) viruses isolated from dead wild birds in Hong Kong showed that these isolates belonged to 2 antigenically distinct virus groups: clades 2.3.4 and 2.3.2. Although research has shown that clade 2.3.4 viruses are established in poultry in Asia, the emergence of clade 2.3.2 viruses in nonpasserine birds from Hong Kong, Japan, and Russia raises the possibility that this virus lineage may have become established in wild birds.

AB - From January 2004 through June 2008, surveillance of dead wild birds in Hong Kong, People's Republic of China, periodically detected highly pathogenic avian influenza (HPAI) viruses (H5N1) in individual birds from different species. During this period, no viruses of subtype H5N1 were detected in poultry on farms and in markets in Hong Kong despite intensive surveillance. Thus, these findings in wild birds demonstrate the potential for wild birds to disseminate HPAI viruses (H5N1) to areas otherwise free from the viruses. Genetic and antigenic characterization of 47 HPAI (H5N1) viruses isolated from dead wild birds in Hong Kong showed that these isolates belonged to 2 antigenically distinct virus groups: clades 2.3.4 and 2.3.2. Although research has shown that clade 2.3.4 viruses are established in poultry in Asia, the emergence of clade 2.3.2 viruses in nonpasserine birds from Hong Kong, Japan, and Russia raises the possibility that this virus lineage may have become established in wild birds.

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Characterization of avian influenza viruses A (H5N1) from wild birds, Hong Kong, 2004-2008

Abstract

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