Characterization of anticonvulsant and antiepileptogenic potential of thymol in various experimental models

Jayant Sancheti, Mohmad Farooq Shaikh, Rahul Chaudhari, Gauresh Somani, Sachin Patil, Pankaj Jain, Sadhana Sathaye

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    Abstract

    The present study was to investigate the anticonvulsant and antiepileptogenic potential of thymol. Anticonvulsant activity of thymol (5-100 mg/kg i.p.) was studied using maximal electroshock, pentylenetetrazole (PTZ), strychnine and 4-aminopyridine (4-AP) models. Thymol at the selected dose was also studied for its effect on locomotion. Antiepileptogenic property of thymol (5-25 mg/kg) was evaluated using PTZ-induced kindling model along with its effect on malondialdehyde and glutathione levels. Thymol (50 and 100 mg/kg, i.p.) showed anticonvulsant activity against maximal electroshock and pentylenetetrazole (66.66 and 83.33 protection at 50 and 100 mg/kg, respectively) model but not against strychnine and 4-aminopyridine models. Thymol exhibited decreased locomotor activity in dose-dependent manner at the same dose range. Thymol at the dose of (25 mg/kg, i.p.) significantly decreased the seizure score, increased glutathione levels and decreased malondialdehyde levels in pentylenetetrazole-induced kindling model. Thymol exhibited significant anticonvulsant and antiepileptogenic property
    Original languageEnglish
    Pages (from-to)59 - 66
    Number of pages8
    JournalNaunyn-Schmiedeberg's Archives of Pharmacology
    Volume387
    Issue number1
    DOIs
    Publication statusPublished - 2014

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