Characterization and implementation of surface-bound PEG-liposomes as an ocular drug delivery system

A. Tarasova; H. J. Griesser; M. D. Willcox; L. Meagher

Characterization and implementation of surface-bound PEG-liposomes as an ocular drug delivery system

A. Tarasova, H. J. Griesser, M. D. Willcox, L. Meagher

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

Abstract

The synthesis, characterization and delivery of poly(ethylene glycol) (PEG)-modified liposomes as drug carriers were investigated. A NeutrAvidin-rich surface was also created onto which PEG-biotinylated liposomes were docked, exploiting the well known high affinity of avidin-like proteins for biotin. It was found that the amount of bound NeutrAvidin was higher on surfaces coupled with biotinylated PEG under cloud point conditions, compared to binding onto surfaces prepared in water. Characterization of biomaterial surfaces modified via diaminopropane (DAP) interlayers, covalently coupled PEG-Biotin and bound NeutrAvidin also demonstrated their suitability as docking platforms for PEGylated liposomes.

Original language	English
Title of host publication	Transactions - 7th World Biomaterials Congress
Number of pages	1
Publication status	Published - 1 Dec 2004
Externally published	Yes
Event	World Biomaterials Congress (WBC) 2004 - Sydney, Australia Duration: 17 May 2004 → 21 May 2004 Conference number: 7th

Conference

Conference	World Biomaterials Congress (WBC) 2004
Country/Territory	Australia
City	Sydney
Period	17/05/04 → 21/05/04

Cite this

@inproceedings{63d78f9827cc49c79628fe8e34eecf77,

title = "Characterization and implementation of surface-bound PEG-liposomes as an ocular drug delivery system",

abstract = "The synthesis, characterization and delivery of poly(ethylene glycol) (PEG)-modified liposomes as drug carriers were investigated. A NeutrAvidin-rich surface was also created onto which PEG-biotinylated liposomes were docked, exploiting the well known high affinity of avidin-like proteins for biotin. It was found that the amount of bound NeutrAvidin was higher on surfaces coupled with biotinylated PEG under cloud point conditions, compared to binding onto surfaces prepared in water. Characterization of biomaterial surfaces modified via diaminopropane (DAP) interlayers, covalently coupled PEG-Biotin and bound NeutrAvidin also demonstrated their suitability as docking platforms for PEGylated liposomes.",

author = "A. Tarasova and Griesser, {H. J.} and Willcox, {M. D.} and L. Meagher",

year = "2004",

month = dec,

day = "1",

language = "English",

isbn = "1877040193",

booktitle = "Transactions - 7th World Biomaterials Congress",

note = "World Biomaterials Congress (WBC) 2004 ; Conference date: 17-05-2004 Through 21-05-2004",

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T1 - Characterization and implementation of surface-bound PEG-liposomes as an ocular drug delivery system

AU - Tarasova, A.

AU - Griesser, H. J.

AU - Willcox, M. D.

AU - Meagher, L.

N1 - Conference code: 7th

PY - 2004/12/1

Y1 - 2004/12/1

N2 - The synthesis, characterization and delivery of poly(ethylene glycol) (PEG)-modified liposomes as drug carriers were investigated. A NeutrAvidin-rich surface was also created onto which PEG-biotinylated liposomes were docked, exploiting the well known high affinity of avidin-like proteins for biotin. It was found that the amount of bound NeutrAvidin was higher on surfaces coupled with biotinylated PEG under cloud point conditions, compared to binding onto surfaces prepared in water. Characterization of biomaterial surfaces modified via diaminopropane (DAP) interlayers, covalently coupled PEG-Biotin and bound NeutrAvidin also demonstrated their suitability as docking platforms for PEGylated liposomes.

AB - The synthesis, characterization and delivery of poly(ethylene glycol) (PEG)-modified liposomes as drug carriers were investigated. A NeutrAvidin-rich surface was also created onto which PEG-biotinylated liposomes were docked, exploiting the well known high affinity of avidin-like proteins for biotin. It was found that the amount of bound NeutrAvidin was higher on surfaces coupled with biotinylated PEG under cloud point conditions, compared to binding onto surfaces prepared in water. Characterization of biomaterial surfaces modified via diaminopropane (DAP) interlayers, covalently coupled PEG-Biotin and bound NeutrAvidin also demonstrated their suitability as docking platforms for PEGylated liposomes.

UR - http://www.scopus.com/inward/record.url?scp=13844299335&partnerID=8YFLogxK

M3 - Conference Paper

AN - SCOPUS:13844299335

SN - 1877040193

SN - 9781877040191

BT - Transactions - 7th World Biomaterials Congress

T2 - World Biomaterials Congress (WBC) 2004

Y2 - 17 May 2004 through 21 May 2004

ER -

Characterization and implementation of surface-bound PEG-liposomes as an ocular drug delivery system

Abstract

Conference

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