Characterization and implementation of surface-bound PEG-liposomes as an ocular drug delivery system

A. Tarasova, H. J. Griesser, M. D. Willcox, L. Meagher

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Abstract

The synthesis, characterization and delivery of poly(ethylene glycol) (PEG)-modified liposomes as drug carriers were investigated. A NeutrAvidin-rich surface was also created onto which PEG-biotinylated liposomes were docked, exploiting the well known high affinity of avidin-like proteins for biotin. It was found that the amount of bound NeutrAvidin was higher on surfaces coupled with biotinylated PEG under cloud point conditions, compared to binding onto surfaces prepared in water. Characterization of biomaterial surfaces modified via diaminopropane (DAP) interlayers, covalently coupled PEG-Biotin and bound NeutrAvidin also demonstrated their suitability as docking platforms for PEGylated liposomes.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
Publication statusPublished - 1 Dec 2004
Externally publishedYes
EventWorld Biomaterials Congress (WBC) 2004 - Sydney, Australia
Duration: 17 May 200421 May 2004
Conference number: 7th

Conference

ConferenceWorld Biomaterials Congress (WBC) 2004
CountryAustralia
CitySydney
Period17/05/0421/05/04

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