Characteristics of Sjogren's syndrome in rheumatoid arthritis

Jing He, Yan Ding, Min Feng, Jianping Guo, Xiaolin Sun, Jing Zhao, Di Yu, Zhanguo Li

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    Abstract

    Objective. To compare features of SS in RA with primary SS and RA without SS.Methods. Patients hospitalized between January 2007 and December 2010 were retrospectively studied. Seventy-four cases of overlap RA and SS (RA/SS) among 509 cases of RA were identified. Cases of SS (n = 187) detected during the same period acted as controls.Results. Among those with RA/SS, there were 46 cases of RA-onset SS and 12 cases of SS-onset RA. Sixteen patients had simultaneous-onset RA and SS. Compared with RA without SS, RA/SS patients had more severe arthritis; a higher incidence of haematological abnormality, fever and rash; and a higher frequency of RF, ANAs and anti-SSA and anti-SSB antibodies (P <0.05). Compared with primary SS, RA/SS patients were older, had more severe arthritis, anaemia and lung involvement; a lower incidence of fever, rash, leucopenia, thrombocytopenia and hyperthyroidism; and a higher frequency of RF, anti-keratin antibody, anti-perinuclear factor and anti-cyclic citrullinated antibodies (P <0.05). Compared with RA and primary SS, RA/SS patients had higher disease activity scores of both RA and SS.Conclusion. RA/SS patients have distinctive features, with more complications and systemic involvement. In addition, disease activity is higher in RA/SS.
    Original languageEnglish
    Pages (from-to)1084 - 1089
    Number of pages6
    JournalRheumatology
    Volume52
    Issue number6
    DOIs
    Publication statusPublished - 2013

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