Characteristics of Pseudomonas Aeruginosa infection in a tertiary neonatal unit

Efrant Harnaen, Tejas N Doctor, Atul Malhotra

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Pseudomonas aeruginosa is associated with fatal late onset sepsis in neonates. Despite advances in neonatal care, the management of Pseudomonas sepsis remains challenging especially when early and definitive therapy is critical. It is a rare cause of neonatal blood stream infections in developed countries and most studies report its occurrence in the setting of an outbreak. We present data from a busy tertiary neonatal intensive care unit in Australia, over a 12-year period. During the study period, we found 6 cases of P. aeruginosa blood stream infection (0.5% of total positive blood culture episodes and 4.2% of total gram-negative culture episodes). All septic (6/6) isolates were between the months of April-June and 41 out of 49 (83%) colonizations of P. aeruginosa were in the first 6 months of the year indicating a seasonal trend. P. aeruginosa sepsis was associated with high mortality (50%) and morbidity (83.3%). All isolates were sensitive to Gentamicin. P. aeruginosa sepsis was not associated with necrotizing enterocolitis in our unit. Our findings indicate that P. aeruginosa infection and colonization seems to follow a seasonal trend. Extremely low gestational age newborns (ELGANs) that have prior P. aeruginosa colonization may benefit from the use of dual anti-Pseudomonal agents.
Original languageEnglish
Number of pages4
JournalInternational Journal of Pediatric Research
Volume1
Issue number2
DOIs
Publication statusPublished - 19 Oct 2015

Keywords

  • pseudomona aeruginosa
  • late onset sepsis
  • colonisation
  • seasonal trend

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