Abstract
Hydroxyl ion attack on aflatoxin B1 (AFB1)-adducted DNA followed by acid hydrolysis releases two AFB1 derivatives, 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl formamido) 9-hydroxy AFB1 (major compound) and 8, 9-dihydro-8-(2-ammino-6-formamido-4-oxo-3,4dihydropyrimid-5-yl amino)9-hydroxy AFB1. The minor compound converts into the major isomer in aqueous dimethylsulphoxide.
Original language | English |
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Pages (from-to) | 723-725 |
Number of pages | 3 |
Journal | Carcinogenesis |
Volume | 3 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1 Dec 1982 |
Externally published | Yes |
Cite this
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Characterisation of the imidazole ring-opened forms of trans-8,9-di-hydro-8-(7-guanyl)9-hydroxy aflatoxin b1. / Hertzog, Paul J.; Smith, John R.lindsay; Garner, R. Colin.
In: Carcinogenesis, Vol. 3, No. 6, 01.12.1982, p. 723-725.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Characterisation of the imidazole ring-opened forms of trans-8,9-di-hydro-8-(7-guanyl)9-hydroxy aflatoxin b1
AU - Hertzog, Paul J.
AU - Smith, John R.lindsay
AU - Garner, R. Colin
PY - 1982/12/1
Y1 - 1982/12/1
N2 - Hydroxyl ion attack on aflatoxin B1 (AFB1)-adducted DNA followed by acid hydrolysis releases two AFB1 derivatives, 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl formamido) 9-hydroxy AFB1 (major compound) and 8, 9-dihydro-8-(2-ammino-6-formamido-4-oxo-3,4dihydropyrimid-5-yl amino)9-hydroxy AFB1. The minor compound converts into the major isomer in aqueous dimethylsulphoxide.
AB - Hydroxyl ion attack on aflatoxin B1 (AFB1)-adducted DNA followed by acid hydrolysis releases two AFB1 derivatives, 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl formamido) 9-hydroxy AFB1 (major compound) and 8, 9-dihydro-8-(2-ammino-6-formamido-4-oxo-3,4dihydropyrimid-5-yl amino)9-hydroxy AFB1. The minor compound converts into the major isomer in aqueous dimethylsulphoxide.
UR - http://www.scopus.com/inward/record.url?scp=0020377111&partnerID=8YFLogxK
U2 - 10.1093/carcin/3.6.723
DO - 10.1093/carcin/3.6.723
M3 - Article
VL - 3
SP - 723
EP - 725
JO - Carcinogenesis
JF - Carcinogenesis
SN - 0143-3334
IS - 6
ER -