Characterisation of the imidazole ring-opened forms of trans-8,9-di-hydro-8-(7-guanyl)9-hydroxy aflatoxin b1

Paul J. Hertzog, John R.lindsay Smith, R. Colin Garner

Research output: Contribution to journal › Article › Research › peer-review

59 Citations (Scopus)

Abstract

Hydroxyl ion attack on aflatoxin B1 (AFB1)-adducted DNA followed by acid hydrolysis releases two AFB1 derivatives, 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl formamido) 9-hydroxy AFB1 (major compound) and 8, 9-dihydro-8-(2-ammino-6-formamido-4-oxo-3,4dihydropyrimid-5-yl amino)9-hydroxy AFB1. The minor compound converts into the major isomer in aqueous dimethylsulphoxide.

Original languageEnglish
Pages (from-to)723-725
Number of pages3
JournalCarcinogenesis
Volume3
Issue number6
DOIs
Publication statusPublished - 1 Dec 1982
Externally publishedYes

Cite this

Hertzog, Paul J. ; Smith, John R.lindsay ; Garner, R. Colin. / Characterisation of the imidazole ring-opened forms of trans-8,9-di-hydro-8-(7-guanyl)9-hydroxy aflatoxin b1. In: Carcinogenesis. 1982 ; Vol. 3, No. 6. pp. 723-725.
@article{90ce7381066d4312b1b6af456aafb573,
title = "Characterisation of the imidazole ring-opened forms of trans-8,9-di-hydro-8-(7-guanyl)9-hydroxy aflatoxin b1",
abstract = "Hydroxyl ion attack on aflatoxin B1 (AFB1)-adducted DNA followed by acid hydrolysis releases two AFB1 derivatives, 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl formamido) 9-hydroxy AFB1 (major compound) and 8, 9-dihydro-8-(2-ammino-6-formamido-4-oxo-3,4dihydropyrimid-5-yl amino)9-hydroxy AFB1. The minor compound converts into the major isomer in aqueous dimethylsulphoxide.",
author = "Hertzog, {Paul J.} and Smith, {John R.lindsay} and Garner, {R. Colin}",
year = "1982",
month = "12",
day = "1",
doi = "10.1093/carcin/3.6.723",
language = "English",
volume = "3",
pages = "723--725",
journal = "Carcinogenesis",
issn = "0143-3334",
publisher = "Oxford University Press",
number = "6",

}

Hertzog, PJ, Smith, JRL & Garner, RC 1982, 'Characterisation of the imidazole ring-opened forms of trans-8,9-di-hydro-8-(7-guanyl)9-hydroxy aflatoxin b1', Carcinogenesis, vol. 3, no. 6, pp. 723-725. https://doi.org/10.1093/carcin/3.6.723

Characterisation of the imidazole ring-opened forms of trans-8,9-di-hydro-8-(7-guanyl)9-hydroxy aflatoxin b1. / Hertzog, Paul J.; Smith, John R.lindsay; Garner, R. Colin.

In: Carcinogenesis, Vol. 3, No. 6, 01.12.1982, p. 723-725.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Characterisation of the imidazole ring-opened forms of trans-8,9-di-hydro-8-(7-guanyl)9-hydroxy aflatoxin b1

AU - Hertzog, Paul J.

AU - Smith, John R.lindsay

AU - Garner, R. Colin

PY - 1982/12/1

Y1 - 1982/12/1

N2 - Hydroxyl ion attack on aflatoxin B1 (AFB1)-adducted DNA followed by acid hydrolysis releases two AFB1 derivatives, 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl formamido) 9-hydroxy AFB1 (major compound) and 8, 9-dihydro-8-(2-ammino-6-formamido-4-oxo-3,4dihydropyrimid-5-yl amino)9-hydroxy AFB1. The minor compound converts into the major isomer in aqueous dimethylsulphoxide.

AB - Hydroxyl ion attack on aflatoxin B1 (AFB1)-adducted DNA followed by acid hydrolysis releases two AFB1 derivatives, 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl formamido) 9-hydroxy AFB1 (major compound) and 8, 9-dihydro-8-(2-ammino-6-formamido-4-oxo-3,4dihydropyrimid-5-yl amino)9-hydroxy AFB1. The minor compound converts into the major isomer in aqueous dimethylsulphoxide.

UR - http://www.scopus.com/inward/record.url?scp=0020377111&partnerID=8YFLogxK

U2 - 10.1093/carcin/3.6.723

DO - 10.1093/carcin/3.6.723

M3 - Article

VL - 3

SP - 723

EP - 725

JO - Carcinogenesis

JF - Carcinogenesis

SN - 0143-3334

IS - 6

ER -

Hertzog PJ, Smith JRL, Garner RC. Characterisation of the imidazole ring-opened forms of trans-8,9-di-hydro-8-(7-guanyl)9-hydroxy aflatoxin b1. Carcinogenesis. 1982 Dec 1;3(6):723-725. https://doi.org/10.1093/carcin/3.6.723

Access to Document