Characterisation of the imidazole ring-opened forms of trans-8,9-di-hydro-8-(7-guanyl)9-hydroxy aflatoxin b1

Paul J. Hertzog; John R.lindsay Smith; R. Colin Garner

doi:10.1093/carcin/3.6.723

Characterisation of the imidazole ring-opened forms of trans-8,9-di-hydro-8-(7-guanyl)9-hydroxy aflatoxin b₁

Paul J. Hertzog, John R.lindsay Smith, R. Colin Garner

Research output: Contribution to journal › Article › Research › peer-review

61 Citations (Scopus)

Abstract

Hydroxyl ion attack on aflatoxin B₁ (AFB₁)-adducted DNA followed by acid hydrolysis releases two AFB₁ derivatives, 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl formamido) 9-hydroxy AFB₁ (major compound) and 8, 9-dihydro-8-(2-ammino-6-formamido-4-oxo-3,4dihydropyrimid-5-yl amino)9-hydroxy AFB₁. The minor compound converts into the major isomer in aqueous dimethylsulphoxide.

Original language	English
Pages (from-to)	723-725
Number of pages	3
Journal	Carcinogenesis
Volume	3
Issue number	6
DOIs	https://doi.org/10.1093/carcin/3.6.723
Publication status	Published - 1 Dec 1982
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/carcin/3.6.723

Cite this

@article{90ce7381066d4312b1b6af456aafb573,

title = "Characterisation of the imidazole ring-opened forms of trans-8,9-di-hydro-8-(7-guanyl)9-hydroxy aflatoxin b1",

abstract = "Hydroxyl ion attack on aflatoxin B1 (AFB1)-adducted DNA followed by acid hydrolysis releases two AFB1 derivatives, 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl formamido) 9-hydroxy AFB1 (major compound) and 8, 9-dihydro-8-(2-ammino-6-formamido-4-oxo-3,4dihydropyrimid-5-yl amino)9-hydroxy AFB1. The minor compound converts into the major isomer in aqueous dimethylsulphoxide.",

author = "Hertzog, {Paul J.} and Smith, {John R.lindsay} and Garner, {R. Colin}",

year = "1982",

month = dec,

day = "1",

doi = "10.1093/carcin/3.6.723",

language = "English",

volume = "3",

pages = "723--725",

journal = "Carcinogenesis",

issn = "0143-3334",

publisher = "Oxford University Press",

number = "6",

}

TY - JOUR

T1 - Characterisation of the imidazole ring-opened forms of trans-8,9-di-hydro-8-(7-guanyl)9-hydroxy aflatoxin b1

AU - Hertzog, Paul J.

AU - Smith, John R.lindsay

AU - Garner, R. Colin

PY - 1982/12/1

Y1 - 1982/12/1

N2 - Hydroxyl ion attack on aflatoxin B1 (AFB1)-adducted DNA followed by acid hydrolysis releases two AFB1 derivatives, 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl formamido) 9-hydroxy AFB1 (major compound) and 8, 9-dihydro-8-(2-ammino-6-formamido-4-oxo-3,4dihydropyrimid-5-yl amino)9-hydroxy AFB1. The minor compound converts into the major isomer in aqueous dimethylsulphoxide.

AB - Hydroxyl ion attack on aflatoxin B1 (AFB1)-adducted DNA followed by acid hydrolysis releases two AFB1 derivatives, 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl formamido) 9-hydroxy AFB1 (major compound) and 8, 9-dihydro-8-(2-ammino-6-formamido-4-oxo-3,4dihydropyrimid-5-yl amino)9-hydroxy AFB1. The minor compound converts into the major isomer in aqueous dimethylsulphoxide.

UR - http://www.scopus.com/inward/record.url?scp=0020377111&partnerID=8YFLogxK

U2 - 10.1093/carcin/3.6.723

DO - 10.1093/carcin/3.6.723

M3 - Article

C2 - 6811145

AN - SCOPUS:0020377111

SN - 0143-3334

VL - 3

SP - 723

EP - 725

JO - Carcinogenesis

JF - Carcinogenesis

IS - 6

ER -