Characterisation of the imidazole ring-opened forms of trans-8,9-di-hydro-8-(7-guanyl)9-hydroxy aflatoxin b1

Paul J. Hertzog; John R.lindsay Smith; R. Colin Garner

doi:10.1093/carcin/3.6.723

Characterisation of the imidazole ring-opened forms of trans-8,9-di-hydro-8-(7-guanyl)9-hydroxy aflatoxin b₁

Paul J. Hertzog, John R.lindsay Smith, R. Colin Garner

Research output: Contribution to journal › Article › Research › peer-review

59 Citations (Scopus)

Abstract

Hydroxyl ion attack on aflatoxin B₁ (AFB₁)-adducted DNA followed by acid hydrolysis releases two AFB₁ derivatives, 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl formamido) 9-hydroxy AFB₁ (major compound) and 8, 9-dihydro-8-(2-ammino-6-formamido-4-oxo-3,4dihydropyrimid-5-yl amino)9-hydroxy AFB₁. The minor compound converts into the major isomer in aqueous dimethylsulphoxide.

Original language	English
Pages (from-to)	723-725
Number of pages	3
Journal	Carcinogenesis
Volume	3
Issue number	6
DOIs	https://doi.org/10.1093/carcin/3.6.723
Publication status	Published - 1 Dec 1982
Externally published	Yes

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10.1093/carcin/3.6.723

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Cite this

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title = "Characterisation of the imidazole ring-opened forms of trans-8,9-di-hydro-8-(7-guanyl)9-hydroxy aflatoxin b1",

abstract = "Hydroxyl ion attack on aflatoxin B1 (AFB1)-adducted DNA followed by acid hydrolysis releases two AFB1 derivatives, 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl formamido) 9-hydroxy AFB1 (major compound) and 8, 9-dihydro-8-(2-ammino-6-formamido-4-oxo-3,4dihydropyrimid-5-yl amino)9-hydroxy AFB1. The minor compound converts into the major isomer in aqueous dimethylsulphoxide.",

author = "Hertzog, {Paul J.} and Smith, {John R.lindsay} and Garner, {R. Colin}",

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doi = "10.1093/carcin/3.6.723",

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journal = "Carcinogenesis",

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T1 - Characterisation of the imidazole ring-opened forms of trans-8,9-di-hydro-8-(7-guanyl)9-hydroxy aflatoxin b1

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AU - Smith, John R.lindsay

AU - Garner, R. Colin

PY - 1982/12/1

Y1 - 1982/12/1

N2 - Hydroxyl ion attack on aflatoxin B1 (AFB1)-adducted DNA followed by acid hydrolysis releases two AFB1 derivatives, 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl formamido) 9-hydroxy AFB1 (major compound) and 8, 9-dihydro-8-(2-ammino-6-formamido-4-oxo-3,4dihydropyrimid-5-yl amino)9-hydroxy AFB1. The minor compound converts into the major isomer in aqueous dimethylsulphoxide.

AB - Hydroxyl ion attack on aflatoxin B1 (AFB1)-adducted DNA followed by acid hydrolysis releases two AFB1 derivatives, 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl formamido) 9-hydroxy AFB1 (major compound) and 8, 9-dihydro-8-(2-ammino-6-formamido-4-oxo-3,4dihydropyrimid-5-yl amino)9-hydroxy AFB1. The minor compound converts into the major isomer in aqueous dimethylsulphoxide.

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