Characterisation of the imidazole ring-opened forms of trans-8,9-di-hydro-8-(7-guanyl)9-hydroxy aflatoxin b1

Paul J. Hertzog, John R.lindsay Smith, R. Colin Garner

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59 Citations (Scopus)

Abstract

Hydroxyl ion attack on aflatoxin B1 (AFB1)-adducted DNA followed by acid hydrolysis releases two AFB1 derivatives, 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl formamido) 9-hydroxy AFB1 (major compound) and 8, 9-dihydro-8-(2-ammino-6-formamido-4-oxo-3,4dihydropyrimid-5-yl amino)9-hydroxy AFB1. The minor compound converts into the major isomer in aqueous dimethylsulphoxide.

Original languageEnglish
Pages (from-to)723-725
Number of pages3
JournalCarcinogenesis
Volume3
Issue number6
DOIs
Publication statusPublished - 1 Dec 1982
Externally publishedYes

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