Characterisation of leucocytic somatic cells in bovine milk

R. Schmaltz, B. Bhogal, J. Wang, Y. Y. Wang, C. R. Mackay, S. S. Chen, L. Larson

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The mammary gland is of cutaneous origin with stromal leucocytic infiltrates and it excretes leucocytes in the milk. Milk T lymphocytes are highly enriched by sedimenting milk somatic cells in a 43 per cent preformed Percoll gradient. Thirty to 54 per cent of leucocytes, harvested from the upper Percoll band, belong to CD2+ CD3+ T lymphocytes These milk T lymphocytes are mature CD4+, or CD8+ single positive T cells, expressing CD44, CD26, and B1 integrin, but not Lam-1. Milk T lymphocyte subsets may play an important role in regional immunosurveillance of the mammary epithelia and stroma. Selective mechanisms may account for the trafficking of this activated, memory T lymphocyte subset in the gland.

Original languageEnglish
Pages (from-to)179-181
Number of pages3
JournalResearch in Veterinary Science
Issue number2
Publication statusPublished - 1 Jan 1996
Externally publishedYes

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