Changing neurodevelopment at 8 years in children born extremely preterm since the 1990s

Jeanie L.Y. Cheong, Peter J. Anderson, Alice C. Burnett, Gehan Roberts, Noni Davis, Leah Hickey, Elizabeth Carse, Lex W Doyle, Victorian Infant Collaborative Study Group

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background and Objectives: Survival of extremely preterm (EP; <28 weeks' gestation) infants has increased over the last 2 decades. Equivalent reductions in developmental morbidity in early childhood have not been consistently reported. The aim of this study was to determine trends in neurodevelopmental outcomes at 8 years of age of children born EP (22-27 completed weeks' gestation) over the past 2 decades. Methods: Population-based cohorts of all EP survivors born in the state of Victoria, Australia in 1991-1992, 1997, and 2005 were recruited at birth. At 8 years of age, general intelligence (IQ), academic achievement, and neurosensory status were assessed. Major neurosensory disability was defined as any of moderate or severe cerebral palsy, IQ <-2 SD relative to term controls, blindness, or deafness. Results: Rates of major neurosensory disability were similar in all eras (1991-1992, 18%; 1997, 15%; 2005, 18%), as were rates of IQ <-2 SD, cerebral palsy, blindness, and deafness. Mean z scores for IQ were similar across eras, but there was some evidence that scores for academic achievement were lower in 2005 than in 1997, and the odds of having academic problems were higher in 2005 than in both earlier eras. These outcomes were not explained by differences in known perinatal care or sociodemographic variables between eras. Conclusions: Contrary to expectations, rates of major neurosensory disability have not improved, and academic performance is poorer at early school age in 2005 than in earlier eras for EP children born in the state of Victoria, Australia.

Original languageEnglish
Article numbere20164086
Number of pages8
JournalPediatrics
Volume139
Issue number6
DOIs
Publication statusPublished - 1 Jun 2017
Externally publishedYes

Cite this

Cheong, J. L. Y., Anderson, P. J., Burnett, A. C., Roberts, G., Davis, N., Hickey, L., ... Victorian Infant Collaborative Study Group (2017). Changing neurodevelopment at 8 years in children born extremely preterm since the 1990s. Pediatrics, 139(6), [e20164086]. https://doi.org/10.1542/peds.2016-4086
Cheong, Jeanie L.Y. ; Anderson, Peter J. ; Burnett, Alice C. ; Roberts, Gehan ; Davis, Noni ; Hickey, Leah ; Carse, Elizabeth ; Doyle, Lex W ; Victorian Infant Collaborative Study Group. / Changing neurodevelopment at 8 years in children born extremely preterm since the 1990s. In: Pediatrics. 2017 ; Vol. 139, No. 6.
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abstract = "Background and Objectives: Survival of extremely preterm (EP; <28 weeks' gestation) infants has increased over the last 2 decades. Equivalent reductions in developmental morbidity in early childhood have not been consistently reported. The aim of this study was to determine trends in neurodevelopmental outcomes at 8 years of age of children born EP (22-27 completed weeks' gestation) over the past 2 decades. Methods: Population-based cohorts of all EP survivors born in the state of Victoria, Australia in 1991-1992, 1997, and 2005 were recruited at birth. At 8 years of age, general intelligence (IQ), academic achievement, and neurosensory status were assessed. Major neurosensory disability was defined as any of moderate or severe cerebral palsy, IQ <-2 SD relative to term controls, blindness, or deafness. Results: Rates of major neurosensory disability were similar in all eras (1991-1992, 18{\%}; 1997, 15{\%}; 2005, 18{\%}), as were rates of IQ <-2 SD, cerebral palsy, blindness, and deafness. Mean z scores for IQ were similar across eras, but there was some evidence that scores for academic achievement were lower in 2005 than in 1997, and the odds of having academic problems were higher in 2005 than in both earlier eras. These outcomes were not explained by differences in known perinatal care or sociodemographic variables between eras. Conclusions: Contrary to expectations, rates of major neurosensory disability have not improved, and academic performance is poorer at early school age in 2005 than in earlier eras for EP children born in the state of Victoria, Australia.",
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Cheong, JLY, Anderson, PJ, Burnett, AC, Roberts, G, Davis, N, Hickey, L, Carse, E, Doyle, LW & Victorian Infant Collaborative Study Group 2017, 'Changing neurodevelopment at 8 years in children born extremely preterm since the 1990s' Pediatrics, vol. 139, no. 6, e20164086. https://doi.org/10.1542/peds.2016-4086

Changing neurodevelopment at 8 years in children born extremely preterm since the 1990s. / Cheong, Jeanie L.Y.; Anderson, Peter J.; Burnett, Alice C.; Roberts, Gehan; Davis, Noni; Hickey, Leah ; Carse, Elizabeth; Doyle, Lex W; Victorian Infant Collaborative Study Group.

In: Pediatrics, Vol. 139, No. 6, e20164086, 01.06.2017.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Changing neurodevelopment at 8 years in children born extremely preterm since the 1990s

AU - Cheong, Jeanie L.Y.

AU - Anderson, Peter J.

AU - Burnett, Alice C.

AU - Roberts, Gehan

AU - Davis, Noni

AU - Hickey, Leah

AU - Carse, Elizabeth

AU - Doyle, Lex W

AU - Victorian Infant Collaborative Study Group

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AB - Background and Objectives: Survival of extremely preterm (EP; <28 weeks' gestation) infants has increased over the last 2 decades. Equivalent reductions in developmental morbidity in early childhood have not been consistently reported. The aim of this study was to determine trends in neurodevelopmental outcomes at 8 years of age of children born EP (22-27 completed weeks' gestation) over the past 2 decades. Methods: Population-based cohorts of all EP survivors born in the state of Victoria, Australia in 1991-1992, 1997, and 2005 were recruited at birth. At 8 years of age, general intelligence (IQ), academic achievement, and neurosensory status were assessed. Major neurosensory disability was defined as any of moderate or severe cerebral palsy, IQ <-2 SD relative to term controls, blindness, or deafness. Results: Rates of major neurosensory disability were similar in all eras (1991-1992, 18%; 1997, 15%; 2005, 18%), as were rates of IQ <-2 SD, cerebral palsy, blindness, and deafness. Mean z scores for IQ were similar across eras, but there was some evidence that scores for academic achievement were lower in 2005 than in 1997, and the odds of having academic problems were higher in 2005 than in both earlier eras. These outcomes were not explained by differences in known perinatal care or sociodemographic variables between eras. Conclusions: Contrary to expectations, rates of major neurosensory disability have not improved, and academic performance is poorer at early school age in 2005 than in earlier eras for EP children born in the state of Victoria, Australia.

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