The present study examined the elemental distribution with depth from the surface of Bioglass 45S5 immersed in simulated body fluid (SBF) in the presence or absence of proteins derived from foetal calf serum for 960 h using energy dispersive spectroscopy (EDS). The changes in elemental composition of the surface of Bioglass were also analysed with EDS for different immersion times (10 min to 960 h) before and after immersion in SBF with or without proteins. The presence of proteins consistently altered the elemental composition of Bioglass with depth from the surface, although the development of a silica rich layer was similar in both the presence or absence of proteins. In the presence of proteins the accumulation of calcium phosphate at the surface of Bioglass was slower, formed a narrower layer and had lower concentrations of calcium and phosphate than the calcium phosphate rich layer that developed in SBF alone.
|Number of pages||5|
|Journal||Journal of Materials Science-Materials in Medicine|
|Publication status||Published - Dec 1995|