Changes in repeat number, sequence, and reading frame in S-antigen genes of Plasmodium falciparum.

R. B. Saint, R. L. Coppel, A. F. Cowman, G. V. Brown, P. T. Shi, N. Barzaga, D. J. Kemp, R. F. Anders

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The S antigens from different isolates of Plasmodium falciparum exhibit extensive size, charge, and serological diversity. We show here that the S-antigen genes behave as multiple alleles of a single locus. The size heterogeneity results from different numbers, lengths, and/or sequences of tandem repeat units encoded within the S-antigen genes. Two genes studied here encode antigenically different S antigens but nevertheless have closely related tandem repeat sequences. We show that antigenic differences can arise because repeats are translated in different reading frames.

Original languageEnglish
Pages (from-to)2968-2973
Number of pages6
JournalMolecular and Cellular Biology
Issue number8
Publication statusPublished - 1 Jan 1987
Externally publishedYes

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