Changes in choice evoked brain activations after a weight loss intervention in adolescents

Fernanda Mata, Juan Verdejo-Roman, Carles Soriano-Mas, Murat Yucel, Antonio Verdejo-Garcia

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)


This study was aimed to investigate if treatment-related success in weight loss (i.e., reductions of BMI and fat percentage) is linked to significant changes in choice evoked brain activity in adolescents with excess weight. Sixteen adolescents with excess weight (age range: 12-18; BMI range: 22-36) performed the Risky-Gains Task during functional Magnetic Resonance Imaging (fMRI) both before and after a 12-week weight loss intervention. Success in weight loss was selectively associated with increased activation in the anterior insula. We concluded that adolescents with the greatest increases in activation of the insula-related interoceptive neural circuitry also show greater reductions in BMI and fat mass
Original languageEnglish
Pages (from-to)113-117
Number of pages5
Publication statusPublished - 1 Aug 2016


  • Decision-making
  • Insula
  • Weight loss
  • Adolescents

Cite this